Lamotrigine augmentation in patients with schizophrenia who show partial response to clozapine treatment.
Yazarlar (7)
A. Elif Anil Yagcioglu
Suha Yagcioglu
Sevilay Karahan
Oguzhan Karci
S. Can Gurel
M. Kazim Yazici
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | SCHIZOPHRENIA RESEARCH (Q1) | ||
| Dergi ISSN | 0920-9964 Dergi Bilgileri (2013) | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2013 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-01-2013 |
| Cilt / Sayı / Sayfa | 143 / 1 / 207–214 | DOI | 10.1016/j.schres.2012.11.006 |
| Makale Linki | https://www.sciencedirect.com/science/article/pii/S0920996412006202 | ||
| UAK Araştırma Alanları |
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| Özet |
| BACKGROUND Several placebo controlled studies investigating lamotrigine augmentation of clozapine in schizophrenia patients with partial response have shown varying results. The aim of this study was to further investigate the efficacy and safety of this augmentation strategy, and its effect on the glutamatergic system through utilizing mismatch negativity (MMN) component of auditory event related potentials. METHODS The study was designed to evaluate the efficacy and safety of lamotrigine augmentation of clozapine in a 12-week, double-blind, placebo-controlled, prospective, randomized design. Thirty-four patients diagnosed according to DSM-IV schizophrenia criteria and with partial response to clozapine were included. Patients were randomized to 25mg/day of lamotrigine or placebo, gradually increasing up to 200mg/day on the 6th week. The change in psychopathology was assessed with Positive and … |
| Anahtar Kelimeler |
| Schizophrenia | Clozapine | Augmentation | Lamotrigine | Mismatch negativity |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 27 |
| Google Scholar | 57 |