| Yazarlar (8) |
Doç. Dr. Emrah ÇIĞRI
Kastamonu Üniversitesi, Türkiye |
Funda Çatan İnan
Bilecik Şeyh Edebali Üniversitesi, Türkiye |
Doç. Dr. Sedat GÜLTEN
Kastamonu Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Mehmet Akif BİLDİRİCİ
Kastamonu Üniversitesi, Türkiye |
|
Ayşe Ece Gökkaya
Kastamonu Üniversitesi, Türkiye |
|
Metin Asıleren
Kastamonu Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Fethiye YILDIZ
Kastamonu Üniversitesi, Türkiye |
|
Hilmi Onur Kabukçu
Kastamonu Üniversitesi, Türkiye |
| Özet |
| Highlights: Our article examines the effects of SPMs on transient neonatal tachypnea, a common condition in newborns. This study is the first clinical study conducted in this area. What are the main findings? LXA4 and RvD1 levels were found to be lower in infants with severe TTN. RvD1 and PLR are significant in predicting infants with severe TTN. What is the implication of the main finding? Infants with high LXA4 and RvD1 levels have milder TTN. RvD1 and PLR are specific and sensitive biomarkers in predicting infants with severe TTN. Objective: Transient tachypnea of the newborn (TTN) is a common condition observed in neonates. Since its management often requires intensive care and leads to maternal–infant separation, it is a major source of parental concern. The present study aimed to evaluate the effects of lipoxin A4 and resolvin D1 on the clinical course of TTN and to determine whether complete blood count parameters could serve as predictors of disease severity. Materials and Methods: A total of 62 neonates admitted to the neonatal intensive care unit with a diagnosis of TTN were included. According to Silverman scoring, infants were divided into a mild group (n = 31) and a severe group (n = 31). Lipoxin A4 and resolvin D1 levels, together with complete blood count parameters, were compared between the two groups. Logistic regression and receiver operating characteristic (ROC) curve analyses were performed to assess the predictive value of these parameters for the clinical course. Results: Serum lipoxin A4 (p = 0.005) and resolvin D1 (p = 0.002) levels were significantly higher in the mild group compared with the severe group, whereas the neutrophil-to-lymphocyte ratio (p = 0.044) and platelet-to-lymphocyte ratio (p = 0.027) were significantly lower. Resolvin D1 and the platelet-to-lymphocyte ratio were identified as significant predictors of severe disease. In predicting a mild course, lipoxin A4 demonstrated the highest sensitivity (80.6%), while resolvin D1 exhibited the highest specificity (87.1%). Conclusions: Lipoxin A4 and resolvin D1 appear to play a protective role in preventing severe clinical progression of transient tachypnea of the newborn. |
| Anahtar Kelimeler |
| lipoxin | resolvin | transient tachypnea of the newborn |
| Makale Türü |
Özgün Makale
|
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Children |
| Dergi ISSN | 2227-9067 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 10-2025 |
| Cilt No | 12 |
| Sayı | 10 |
| Doi Numarası | 10.3390/children12101421 |
| Atıf Sayıları |
