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Evaluation of the Effects of Lipoxin A4 and Resolvin D1 on the Severity of Transient Tachypnea of the Newborn: A Prospective Study   
Yazarlar (8)
Doç. Dr. Emrah ÇIĞRI Doç. Dr. Emrah ÇIĞRI
Kastamonu Üniversitesi, Türkiye
Funda Çatan İnan
Bilecik Şeyh Edebali Üniversitesi, Türkiye
Doç. Dr. Sedat GÜLTEN Doç. Dr. Sedat GÜLTEN
Kastamonu Üniversitesi, Türkiye
Dr. Öğr. Üyesi Mehmet Akif BİLDİRİCİ Dr. Öğr. Üyesi Mehmet Akif BİLDİRİCİ
Kastamonu Üniversitesi, Türkiye
Ayşe Ece Gökkaya
Metin Asıleren
Dr. Öğr. Üyesi Fethiye YILDIZ Dr. Öğr. Üyesi Fethiye YILDIZ
Kastamonu Üniversitesi, Türkiye
Hilmi Onur Kabukçu
Kastamonu Üniversitesi, Türkiye
Devamını Göster
Özet
Highlights Our article examines the effects of SPMs on transient neonatal tachypnea, a common condition in newborns. This study is the first clinical study conducted in this area. What are the main findings? LXA4 and RvD1 levels were found to be lower in infants with severe TTN. RvD1 and PLR are significant in predicting infants with severe TTN. What is the implication of the main finding? Infants with high LXA4 and RvD1 levels have milder TTN. RvD1 and PLR are specific and sensitive biomarkers in predicting infants with severe TTN. Abstract Objective: Transient tachypnea of the newborn (TTN) is a common condition observed in neonates. Since its management often requires intensive care and leads to maternal–infant separation, it is a major source of parental concern. The present study aimed to evaluate the effects of lipoxin A4 and resolvin D1 on the clinical course of TTN and to determine whether complete blood count parameters could serve as predictors of disease severity. Materials and Methods: A total of 62 neonates admitted to the neonatal intensive care unit with a diagnosis of TTN were included. According to Silverman scoring, infants were divided into a mild group (n = 31) and a severe group (n = 31). Lipoxin A4 and resolvin D1 levels, together with complete blood count parameters, were compared between the two groups. Logistic regression and receiver operating characteristic (ROC) curve analyses were performed to assess …
Anahtar Kelimeler
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale
Dergi Adı Children
Dergi ISSN 2227-9067 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler SCI-Expanded
Dergi Grubu Q2
Makale Dili İngilizce
Basım Tarihi 10-2025
Cilt No 12
Sayı 1421
Doi Numarası 10.3390/children12101421
Makale Linki https://doi.org/10.3390/children12101421