| Yazarlar (4) |
Dr. Öğr. Üyesi Yener YAZĞAN
Kastamonu Üniversitesi, Türkiye |
Doç. Dr. Kıymet Kübra TÜFEKCİ
Kastamonu Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Betül YAZĞAN
Kastamonu Üniversitesi, Türkiye |
Doç. Dr. Musa TATAR
Kastamonu Üniversitesi, Türkiye |
| Özet |
| Electromagnetic field (EMF) exposure, unavoidable in modern life, is linked to oxidative stress and ferroptosis, processes linked to neurodevelopmental disorders. This study investigated the effects of EMF exposure during different pregnancy trimesters on rat offspring trigeminal ganglia (TGs), focusing on transient receptor potential melastatin 2 (TRPM2) ion channels, and assessed the neuroprotective potential of ferrostatin-1 (Fer), a ferroptosis inhibitor, against EMF-induced damage. Pregnant rats were exposed to 900 MHz EMF for 2 h/day during early (1--7 days, EMF 1), mid (8--14 days, EMF 2), or late (15--21 days, EMF 3) gestation. Fer (2.5 µmol/kg, i.p.) was administered immediately after daily EMF exposure in Fer treatment groups. Offspring TG tissues were analyzed on postnatal Day 28 using histopathological, immunohistochemical, and biochemical approaches. EMF exposure significantly reduced antioxidant capacity and elevated lipid peroxidation, reactive oxygen species (ROS), pro-inflammatory cytokines, apoptotic markers, and TRPM2 activation, with the most pronounced alterations in mid-gestation exposure. Fer administration largely normalized these parameters and reduced structural damage in TG. In conclusion, these findings suggest that prenatal EMF triggers ferroptotic/apoptotic neurodegeneration via TRPM2, and that Fer holds promise as a neuroprotective agent. |
| Anahtar Kelimeler |
| electromagnetic field | ferroptosis | glutathione peroxidase 4 (GPX4) | oxidative stress | transient receptor potential melastatin 2 (TRPM2) |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı |
Developmental Neurobiology
|
| Dergi ISSN | 1932-8451 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 10-2025 |
| Cilt No | 85 |
| Sayı | 4 |
| Sayfalar | 23013 / 0 |
| Doi Numarası | 10.1002/dneu.23013 |
| Makale Linki | https://onlinelibrary.wiley.com/doi/10.1002/dneu.23013 |
| Atıf Sayıları |
