Effect of 900 MHz Electromagnetic Field Exposure During Different Trimesters of Pregnancy on TRPM2‐Mediated Ferroptosis and Neurotoxicity in the Trigeminal Ganglion of Rats: Protective Role of Ferrostatin‐1
Yazarlar (4)
Doç. Dr. Yener YAZĞAN Kastamonu Üniversitesi, Türkiye
Doç. Dr. Kıymet Kübra TÜFEKCİ Kastamonu Üniversitesi, Türkiye
Dr. Öğr. Üyesi Betül YAZĞAN Kastamonu Üniversitesi, Türkiye
Doç. Dr. Musa TATAR Kastamonu Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Developmental Neurobiology (Q2) | ||
| Dergi ISSN | 1932-8451 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 10-2025 |
| Cilt / Sayı / Sayfa | 85 / 4 / 1–16 | DOI | 10.1002/dneu.23013 |
| Makale Linki | https://doi.org/10.1002/dneu.23013 | ||
| UAK Araştırma Alanları |
Histoloji ve Embriyoloji
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| Özet |
| Electromagnetic field (EMF) exposure, unavoidable in modern life, is linked to oxidative stress and ferroptosis, processes linked to neurodevelopmental disorders. This study investigated the effects of EMF exposure during different pregnancy trimesters on rat offspring trigeminal ganglia (TGs), focusing on transient receptor potential melastatin 2 (TRPM2) ion channels, and assessed the neuroprotective potential of ferrostatin‐1 (Fer), a ferroptosis inhibitor, against EMF‐induced damage. Pregnant rats were exposed to 900 MHz EMF for 2 h/day during early (1–7 days, EMF 1), mid (8–14 days, EMF 2), or late (15–21 days, EMF 3) gestation. Fer (2.5 µmol/kg, i.p.) was administered immediately after daily EMF exposure in Fer treatment groups. Offspring TG tissues were analyzed on postnatal Day 28 using histopathological, immunohistochemical, and biochemical approaches. EMF exposure significantly reduced … |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 1 |