| Yazarlar (10) |
Prof. Dr. Yasemin ÇELİK ALTUNOĞLU
Kastamonu Üniversitesi, Türkiye |
Arş. Gör. Mustafa ÖÇAL
Kastamonu Üniversitesi, Türkiye |
Prof. Dr. Mehmet Cengiz BALOĞLU
Kastamonu Üniversitesi, Türkiye |
Alsideeq Abdulsalam Ahmed Aboujanah
Kastamonu Üniversitesi, Türkiye |
|
Erdoğan Horuz
Kastamonu Üniversitesi, Türkiye |
|
Eulogio J. Llorent-Martínez
Universidad de Jaén, İspanya |
|
Abdullahi Ibrahim Uba
İstanbul Arel Üniversitesi, Türkiye |
|
Irina Lazorova
Medical University of Sofia |
|
Gökhan Zengin
Selçuk Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Kerim GÜNEY
Kastamonu Üniversitesi, Türkiye |
| Özet |
| Inula viscosa is a common medicinal plant and is mostly spread in Mediterranean countries. The current study analyses I. viscosa extracts for antimicrobial capacity, phenolic content, antioxidant, enzyme inhibition, and molecular modeling. The extracts' anticancer potential in prostate and breast cancer cells was evaluated, and their anti-metastatic and molecular activities were analyzed through gene expression. The most prevalent substances in the methanol extract of I. viscosa are phenolic acids, which include derivatives of caffeic acid and mono-, di-, and tri-caffeoylquinic acids. Dicaffeoylquinic acids represented 88 % of the quantified phenolics. The methanol extract showed a 50 % inhibitor concentration (IC50) of 101.4 μg/mL at 48 h in PC3 cells. Autophagy-related genes were found to be down-regulated in all three cancer cells. Regarding antimetastatic activity, the wound width remained ∼96 % at 48 h after ... |
| Anahtar Kelimeler |
| anticancer | antimicrobial | antioxidant | autophagy | |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Zeitschrift für Naturforschung C |
| Dergi ISSN | 0939-5075 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q3 |
| Makale Dili | İngilizce |
| Basım Tarihi | 10-2025 |
| Sayı | 1 |
| Doi Numarası | 10.1515/znc-2025-0189 |
| Makale Linki | https://doi.org/10.1515/znc-2025-0189 |
| Atıf Sayıları |
