| Yazarlar (10) |
Prof. Dr. Yasemin ÇELİK ALTUNOĞLU
Kastamonu Üniversitesi, Türkiye |
Arş. Gör. Mustafa ÖÇAL
Kastamonu Üniversitesi, Türkiye |
Prof. Dr. Mehmet Cengiz BALOĞLU
Kastamonu Üniversitesi, Türkiye |
Alsideeq Abdulsalam Ahmed Aboujanah
Kastamonu Üniversitesi, Türkiye |
|
Erdogan Horuz
Kastamonu Üniversitesi, Türkiye |
|
Eulogio J. Llorent-Martinez
Universidad De Jaén, İspanya |
|
Abdullahi Ibrahim Uba
İstanbul Arel Üniversitesi, Türkiye |
|
Irina Lazarova
Medical University Of Sofia, Bulgaristan |
|
Gokhan Zengin
Selçuk Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Kerim GÜNEY
Kastamonu Üniversitesi, Türkiye |
| Özet |
| is a common medicinal plant and is mostly spread in Mediterranean countries. The current study analyses extracts for antimicrobial capacity, phenolic content, antioxidant, enzyme inhibition, and molecular modeling. The extracts' anticancer potential in prostate and breast cancer cells was evaluated, and their anti-metastatic and molecular activities were analyzed through gene expression. The most prevalent substances in the methanol extract of are phenolic acids, which include derivatives of caffeic acid and mono-, di-, and tri-caffeoylquinic acids. Dicaffeoylquinic acids represented 88 % of the quantified phenolics. The methanol extract showed a 50 % inhibitor concentration (IC) of 101.4 μg/mL at 48 h in PC3 cells. Autophagy-related genes were found to be down-regulated in all three cancer cells. Regarding antimetastatic activity, the wound width remained ∼96 % at 48 h after ethyl acetate treatment in MCF-7 cells. The water extract had the highest total phenolic content and the strongest antioxidant capacity, followed by the methanol extract. Modest binding potential to B-cell leukemia-2 (Bcl-2) was observed with caffeoylquinic acid and caffeic acid derivatives, which may be related to pro-apoptotic/anticancer effects. Our results suggested that can be considered as an effective raw material for designing health-promoting applications. |
| Anahtar Kelimeler |
| anticancer | antimicrobial | antioxidant | autophagy | |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES |
| Dergi ISSN | 0939-5075 Wos Dergi Scopus Dergi |
| Dergi Grubu | Q3 |
| Makale Dili | İngilizce |
| Basım Tarihi | 10-2025 |
| Sayı | 1 |
| Doi Numarası | 10.1515/znc-2025-0189 |
| Atıf Sayıları |
