Pharmacokinetics and bioavailability of cefuroxime in Nile tilapia (Oreochromis niloticus)

Çorum, Orhan; Çorum, Duygu Durna; Üney, Kamil; Marin, Pedro; Yıldırım, Önder; TERZİ, Ertuğrul; Gonzales, Ruby C.; Arrıesgado, Dan M.; Navarro, Victor R.; BİLEN, Soner; SÖNMEZ, Adem Yavuz

doi:10.1007/s11259-025-10974-8

Pharmacokinetics and bioavailability of cefuroxime in Nile tilapia (Oreochromis niloticus)

Yazarlar (11)

Prof. Dr. Orhan Çorum Hatay Mustafa Kemal Üniversitesi, Türkiye

Doç. Dr. Duygu Durna Çorum Hatay Mustafa Kemal Üniversitesi, Türkiye

Pedro Marin
Universidad De Murcia, İspanya

Prof. Dr. Önder Yıldırım Muğla Sıtkı Koçman Üniversitesi, Türkiye

Doç. Dr. Ertuğrul TERZİ Kastamonu Üniversitesi, Türkiye

Ruby C. Gonzales
Mindanao State University At Naawan, Filipinler

Dan M. Arrıesgado
Mindanao State University At Naawan, Filipinler

Victor R. Navarro
Mindanao State University At Naawan, Filipinler

Doç. Dr. Soner BİLEN Kastamonu Üniversitesi, Türkiye

Doç. Dr. Adem Yavuz SÖNMEZ Kastamonu Üniversitesi, Türkiye

Prof. Dr. Kamil Üney Selçuk Üniversitesi, Türkiye

Makale Türü	Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı	Veterinary Research Communications (Q2)
Dergi ISSN	0165-7380 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler	SCI-Expanded
Makale Dili	İngilizce	Basım Tarihi	11-2026
Cilt / Sayı / Sayfa	50 / 1 / 18–0	DOI	10.1007/s11259-025-10974-8
Makale Linki	https://doi.org/10.1007/s11259-025-10974-8
UAK Araştırma Alanları	Su Ürünleri Yetiştiriciliği

Özet

Cefuroxime is a broad-spectrum antibiotic extensively utilized in humans and animals. Although it has been reported as beneficial against certain fish infections, pharmacokinetic studies are lacking. The purpose of this study was to evaluate the pharmacokinetics of cefuroxime following intravascular (IV, n = 72), intraperitoneal (IP, n = 72), intramuscular (IM, n = 72), and oral (n = 72) administration of 20 mg/kg in Nile tilapia (Oreochromis niloticus) maintained at 29 ± 1.5 °C. Two hundred and eighty-eight fish were equally distributed among four treatment groups: IV, IP, IM, and oral. Blood samples were obtained from 6 fish per group at 12 distinct time intervals over a duration of 96 h. Cefuroxime plasma concentrations were quantified with high-performance liquid chromatography and subsequently evaluated through non-compartmental analysis. Following IV injection, the t1/2ʎz was 8.04 h, the Vdss was 1.03 L/kg, and the ClT was 0.14 L/h/kg. The Cmax of cefuroxime was 53.38±4.28 µg/mL at 0.25 h for IP injection, 28.70±3.41 µg/mL at 0.5 h for IM injection, and 6.77±0.81 µg/mL at 1 h for oral administration. Bioavailability was 80.26% (IP), 69.05% (IM), and 24.35% (oral). This study found that a dosing interval of 24 h for IP and IM injection or 8 h for oral administration is efficient for treating bacteria with a MIC value of ≤ 1 µg/mL. The findings of this study indicate that IP and IM injections of cefuroxime are applicable in tilapia. However, since oral administration is important in aquaculture, studies are needed to develop new formulations with better absorption, to demonstrate therapeutic efficacy in infected fish, and to determine the tissues residue depletion.

Anahtar Kelimeler

Cefuroxime | Different routes | Nile tilapia | Pharmacokinetic

Pdf İndir

BM Sürdürülebilir Kalkınma Amaçları

Atıf Sayıları
Scopus	1

Pharmacokinetics and bioavailability of cefuroxime in Nile tilapia (Oreochromis niloticus)

Dergi Adı	VETERINARY RESEARCH COMMUNICATIONS
Yayıncı	Springer Science and Business Media B.V.
Açık Erişim	Hayır
ISSN	0165-7380
E-ISSN	1573-7446
CiteScore	2,6
SJR	0,568
SNIP	0,887

Pharmacokinetics and bioavailability of cefuroxime in Nile tilapia (Oreochromis niloticus)

Paylaş