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Akademisyenler > Soner BİLEN > Yayın Detayı

Pharmacokinetics and bioavailability of cefuroxime in Nile tilapia (Oreochromis niloticus)   
Yazarlar (11)
Orhan Corum
University Of Hatay Mustafa Kemal, Türkiye
Duygu Durna Corum
University Of Hatay Mustafa Kemal, Türkiye
Pedro Marin
Universidad De Murcia, İspanya
Onder Yildirim
Muğla Sıtkı Koçman Üniversitesi, Türkiye
Doç. Dr. Ertuğrul TERZİ Doç. Dr. Ertuğrul TERZİ
Kastamonu Üniversitesi, Türkiye
Ruby C. Gonzales
Mindanao State University At Naawan, Filipinler
Dan M. Arriesgado
Mindanao State University At Naawan, Filipinler
Victor R. Navarro
Mindanao State University At Naawan, Filipinler
Doç. Dr. Soner BİLEN Doç. Dr. Soner BİLEN
Kastamonu Üniversitesi, Türkiye
Doç. Dr. Adem Yavuz SÖNMEZ Doç. Dr. Adem Yavuz SÖNMEZ
Kastamonu Üniversitesi, Türkiye
Kamil Uney
Selçuk Üniversitesi, Türkiye
Devamını Göster
Özet
Cefuroxime is a broad-spectrum antibiotic extensively utilized in humans and animals. Although it has been reported as beneficial against certain fish infections, pharmacokinetic studies are lacking. The purpose of this study was to evaluate the pharmacokinetics of cefuroxime following intravascular (IV, n = 72), intraperitoneal (IP, n = 72), intramuscular (IM, n = 72), and oral (n = 72) administration of 20 mg/kg in Nile tilapia (Oreochromis niloticus) maintained at 29 ± 1.5 °C. Two hundred and eighty-eight fish were equally distributed among four treatment groups: IV, IP, IM, and oral. Blood samples were obtained from 6 fish per group at 12 distinct time intervals over a duration of 96 h. Cefuroxime plasma concentrations were quantified with high-performance liquid chromatography and subsequently evaluated through non-compartmental analysis. Following IV injection, the t1/2ʎz was 8.04 h, the Vdss was 1.03 L/kg, and the ClT was 0.14 L/h/kg. The Cmax of cefuroxime was 53.38±4.28 µg/mL at 0.25 h for IP injection, 28.70±3.41 µg/mL at 0.5 h for IM injection, and 6.77±0.81 µg/mL at 1 h for oral administration. Bioavailability was 80.26% (IP), 69.05% (IM), and 24.35% (oral). This study found that a dosing interval of 24 h for IP and IM injection or 8 h for oral administration is efficient for treating bacteria with a MIC value of ≤ 1 µg/mL. The findings of this study indicate that IP and IM injections of cefuroxime are applicable in tilapia. However, since oral administration is important in aquaculture, studies are needed to develop new formulations with better absorption, to demonstrate therapeutic efficacy in infected fish, and to determine the tissues residue depletion.
Anahtar Kelimeler
Cefuroxime | Different routes | Nile tilapia | Pharmacokinetic
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale
Dergi Adı Veterinary Research Communications
Dergi ISSN 0165-7380 Wos Dergi Scopus Dergi
Dergi Grubu Q2
Makale Dili İngilizce
Basım Tarihi 02-2026
Cilt No 50
Sayı 1
Doi Numarası 10.1007/s11259-025-10974-8
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
Pharmacokinetics and bioavailability of cefuroxime in Nile tilapia (Oreochromis niloticus)

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