Pharmacokinetics and bioavailability of cefuroxime in Nile tilapia (Oreochromis niloticus)
Yazarlar (11)
Prof. Dr. Orhan Corum University Of Hatay Mustafa Kemal, Türkiye
Doç. Dr. Duygu Durna Corum University Of Hatay Mustafa Kemal, Türkiye
Pedro Marin
Universidad De Murcia, İspanya
Universidad De Murcia, İspanya
Prof. Dr. Onder Yildirim Muğla Sıtkı Koçman Üniversitesi, Türkiye
Doç. Dr. Ertuğrul TERZİ Kastamonu Üniversitesi, Türkiye
Ruby C. Gonzales
Mindanao State University At Naawan, Filipinler
Mindanao State University At Naawan, Filipinler
Dan M. Arriesgado
Mindanao State University At Naawan, Filipinler
Mindanao State University At Naawan, Filipinler
Victor R. Navarro
Mindanao State University At Naawan, Filipinler
Mindanao State University At Naawan, Filipinler
Doç. Dr. Soner BİLEN Kastamonu Üniversitesi, Türkiye
Doç. Dr. Adem Yavuz SÖNMEZ Kastamonu Üniversitesi, Türkiye
Prof. Dr. Kamil Uney Selçuk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Veterinary Research Communications (Q2) | ||
| Dergi ISSN | 0165-7380 Wos Dergi Scopus Dergi | ||
| Makale Dili | İngilizce | Basım Tarihi | 02-2026 |
| Cilt / Sayı / Sayfa | 50 / 1 / – | DOI | 10.1007/s11259-025-10974-8 |
| Makale Linki | https://link.springer.com/article/10.1007/s11259-025-10974-8 | ||
| UAK Araştırma Alanları |
Ziraat, Orman ve Su Ürünleri
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| Özet |
| Cefuroxime is a broad-spectrum antibiotic extensively utilized in humans and animals. Although it has been reported as beneficial against certain fish infections, pharmacokinetic studies are lacking. The purpose of this study was to evaluate the pharmacokinetics of cefuroxime following intravascular (IV, n= 72), intraperitoneal (IP, n= 72), intramuscular (IM, n= 72), and oral (n= 72) administration of 20 mg/kg in Nile tilapia (Oreochromis niloticus) maintained at 29±1.5 C. Two hundred and eighty-eight fish were equally distributed among four treatment groups: IV, IP, IM, and oral. Blood samples were obtained from 6 fish per group at 12 distinct time intervals over a duration of 96 h. Cefuroxime plasma concentrations were quantified with high-performance liquid chromatography and subsequently evaluated through non-compartmental analysis. Following IV injection, the t 1/2ʎz was 8.04 h, the V dss was 1.03 L/kg, and … |
| Anahtar Kelimeler |
| Cefuroxime | Different routes | Nile tilapia | Pharmacokinetic |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 1 |
| Google Scholar | 20 |
| Google Scholar | 1 |