Plasma and Muscle Pharmacokinetics of Ceftriaxone in Nile Tilapia (Oreochromis niloticus) After Different Administration Routes
Yazarlar (11)
Pedro Marın
Universidad De Murcia, İspanya
Universidad De Murcia, İspanya
Prof. Dr. Orhan Çorum Hatay Mustafa Kemal Üniversitesi, Türkiye
Doç. Dr. Duygu Çorum Hatay Mustafa Kemal Üniversitesi, Türkiye
Elena Badıllo
Universidad De Murcia, İspanya
Universidad De Murcia, İspanya
Marıa Teresa Yuste
Universidad De Murcia, İspanya
Universidad De Murcia, İspanya
Prof. Dr. Önder Yıldırım Muğla Sıtkı Koçman Üniversitesi, Türkiye
Doç. Dr. Ertuğrul TERZİ Kastamonu Üniversitesi, Türkiye
Ruby C Gonzales
Mindanao State University At Naawan, Filipinler
Mindanao State University At Naawan, Filipinler
Dan M Arriesgado
Mindanao State University At Naawan, Filipinler
Mindanao State University At Naawan, Filipinler
Victor R Navarro
Mindanao State University At Naawan, Filipinler
Mindanao State University At Naawan, Filipinler
Prof. Dr. Kamil Üney Selçuk Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Antibiotics (Q1) | ||
| Dergi ISSN | 2079-6382 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 12-2025 |
| Cilt / Sayı / Sayfa | 14 / 12 / 1253–0 | DOI | 10.3390/antibiotics14121253 |
| Makale Linki | https://doi.org/10.3390/antibiotics14121253 | ||
| UAK Araştırma Alanları |
Su Ürünleri Hastalıkları
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| Özet |
| Background/Objectives: The aim of this study was to determine the plasma and muscle pharmacokinetics of ceftriaxone (25 mg/kg) in tilapia after different administration routes. Methods: Two hundred and sixteen fish maintained at 30 ± 1.5 °C were divided equally into three treatment groups: intravascular (IV), intraperitoneal (IP), and intramuscular (IM). Ceftriaxone concentrations were quantified using high-performance liquid chromatography, and pharmacokinetic parameters were calculated by non-compartmental analysis. Results: The plasma total body clearance, volume of distribution at steady state, and elimination half-life (t1/2λz) were 0.22 L/h/kg, 0.85 L/kg, and 5.27 h, respectively. The t1/2λz values were comparable among the IV, IP, and IM injection groups. The peak plasma concentration was 37.71 ± 3.12 µg/mL and 40.51 ± 2.77 µg/mL following IP and IM injection, respectively. The bioavailability was 67.04% for IP and 101.48% for IM. The peak muscle concentration was 9.49 ± 0.75 µg/g for IV, 5.71 ± 0.85 µg/g for IP, and 12.24 ± 2.41 µg/g for IM injection. The AUC0–∞muscle/AUC0–∞plasma ratio was 0.23, 0.18, and 0.30 for the IV, IP, and IM groups, respectively. The AUCmuscle/AUCplasma indicates the ratio of drug penetration into the muscle, and a value less than 1 indicates that ceftriaxone penetrates into muscle tissue at a low ratio. Conclusions: These results indicate that ceftriaxone is well absorbed after IP and IM injections and passes into muscle tissue at a low tissue penetration. Ceftriaxone can be administered via IP and IM injection in Nile tilapia; nevertheless, its therapeutic efficacy requires evaluation. |
| Anahtar Kelimeler |
| bioavailability | ceftriaxone | muscle | Nile tilapia | pharmacokinetic |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |
| Google Scholar | 1 |