Pharmacokinetics and bioavailability of cefuroxime in Nile tilapia (Oreochromis niloticus)
Yazarlar (11)
Prof. Dr. Orhan Çorum Hatay Mustafa Kemal Üniversitesi, Türkiye
Doç. Dr. Duygu Durna Çorum Hatay Mustafa Kemal Üniversitesi, Türkiye
Pedro Marın
Universidad De Murcia, İspanya
Universidad De Murcia, İspanya
Prof. Dr. Önder Yıldırım Muğla Sıtkı Koçman Üniversitesi, Türkiye
Doç. Dr. Ertuğrul TERZİ Kastamonu Üniversitesi, Türkiye
Ruby C Gonzales
Mindanao State University At Naawan, Filipinler
Mindanao State University At Naawan, Filipinler
Dan M Arriesgado
Mindanao State University At Naawan, Filipinler
Mindanao State University At Naawan, Filipinler
Victor R Navarro
Mindanao State University At Naawan, Filipinler
Mindanao State University At Naawan, Filipinler
Doç. Dr. Soner BİLEN Kastamonu Üniversitesi, Türkiye
Doç. Dr. Adem Yavuz SÖNMEZ Kastamonu Üniversitesi, Türkiye
Prof. Dr. Kamil Üney Selçuk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Veterinary Research Communications (Q2) | ||
| Dergi ISSN | 0165-7380 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 02-2026 |
| Cilt / Sayı / Sayfa | 50 / 1 / 1–8 | DOI | 10.1007/s11259-025-10974-8 |
| Makale Linki | https://doi.org/10.1007/s11259-025-10974-8 | ||
| UAK Araştırma Alanları |
Su Ürünleri Hastalıkları
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| Özet |
| Cefuroxime is a broad-spectrum antibiotic extensively utilized in humans and animals. Although it has been reported as beneficial against certain fish infections, pharmacokinetic studies are lacking. The purpose of this study was to evaluate the pharmacokinetics of cefuroxime following intravascular (IV, n= 72), intraperitoneal (IP, n= 72), intramuscular (IM, n= 72), and oral (n= 72) administration of 20 mg/kg in Nile tilapia (Oreochromis niloticus) maintained at 29±1.5 C. Two hundred and eighty-eight fish were equally distributed among four treatment groups: IV, IP, IM, and oral. Blood samples were obtained from 6 fish per group at 12 distinct time intervals over a duration of 96 h. Cefuroxime plasma concentrations were quantified with high-performance liquid chromatography and subsequently evaluated through non-compartmental analysis. Following IV injection, the t 1/2ʎz was 8.04 h, the V dss was 1.03 L/kg, and … |
| Anahtar Kelimeler |
| Cefuroxime | Different routes | Nile tilapia | Pharmacokinetic |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 2 |
| Scopus | 1 |
| Google Scholar | 20 |