Different mechanisms of axitinib and diazepam antiseizure action in pentylenetetrazol-induced kindling model
Yazarlar (5)
Leonid Godlevsky
Dr. Öğr. Üyesi Işınsu Alkan Nevşehir Hacı Bektaş Veli Üniversitesi, Türkiye
Doç. Dr. Kıymet Kübra TÜFEKCİ Kastamonu Üniversitesi, Türkiye
Pervak Mykhailo
Öğr. Gör. Süleyman Kaplan Ondokuz Mayıs Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(ESCI dergilerinde yayınlanan tam makale)
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| Dergi Adı | IBRO NEUROSCIENCE REPORTS | ||
| Dergi ISSN | 2667-2421 Dergi Bilgileri (2025) | ||
| Dergi Tarandığı Indeksler | scopus | ||
| Makale Dili | Türkçe | Basım Tarihi | 12-2025 |
| Cilt / Sayı / Sayfa | 19 / 0 / 668–678 | DOI | 10.1016/j.ibneur.2025.09.005 |
| Makale Linki | https://doi.org/10.1016/j.ibneur.2025.09.005 | ||
| UAK Araştırma Alanları |
Histoloji ve Embriyoloji
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| Özet |
| IntroductionThis study intended to assess the histomorphology characteristics of hippocampal structures and determine the severity of seizures after treatment with the tyrosine kinase B inhibitor axitinib and diazepam in fully developed and postponed period in PTZ-kindled rats.Methods and materialsWistar rats were given PTZ for 21 days until fully developed convulsions were achieved. Two protocols were explored: assessment of seizures immediately after the completion of the kindling (early kindling) and after a two-week post-kindling PTZ-free period. Treatment with axitinib and diazepam was performed before early and postponed kindling seizures assessment, with the consequent collection of brains for histomorphology.ResultsAxitinib and diazepam effectively reduced seizure severity at the early and postponed periods of kindling. Axitinib's antiseizure effectiveness was reduced in the postponed stage of … |
| Anahtar Kelimeler |
| Tyrosine-kinase | PTZ-induce kindling | Diazepam | Dark neurons | Neurodegeneration | Angiogenesis |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |
| Google Scholar | 4 |