A Novel Three-Dimensional-Printed Polycaprolactone/Nanohydroxyapatite-Nanoclay Scaffold for Bone Tissue Engineering Applications
Yazarlar (5)
Saba Nazari Islamic Azad University, Central Tehran Branch, İran
Seyed Ali Poursamar
Biosensor Research Center, Isfahan Ums, İran
Biosensor Research Center, Isfahan Ums, İran
Mitra Naeimi
Islamic Azad University, Central Tehran Branch, İran
Islamic Azad University, Central Tehran Branch, İran
Mohammad Rafienia Biosensor Research Center, Isfahan Ums, İran
Prof. Dr. Majıd MONAJJEMI Islamic Azad University, Central Tehran Branch, İran
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Bionic Engineering (Q1) | ||
| Dergi ISSN | 1672-6529 Wos Dergi Scopus Dergi | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2025 |
| Cilt / Sayı / Sayfa | 22 / 4 / 1863–1880 | DOI | 10.1007/s42235-025-00704-w |
| Özet |
| The field of bone tissue engineering has experienced an increase in prevalence due to the inherent challenge of the natural regeneration of significant bone deformities. This investigation focused on the preparation of Three-Dimensional (3D)-printed Polycaprolactone (PCL) scaffolds with varying proportions of Nanohydroxyapatite (NHA) and Nanoclay (NC), and their physiochemical and biological properties were assessed. The mechanical properties of PCL are satisfactory; however, its hydrophobic nature and long-term degradation hinder its use in scaffold fabrication. NHA and NC have been employed to improve the hydrophilic characteristics, mechanical strength, adhesive properties, biocompatibility, biodegradability, and osteoconductive behavior of PCL. The morphology results demonstrated 3D-printed structures with interconnected rectangular macropores and proper nanoparticle distribution. The sample containing 70 wt% NC showed the highest porosity (65.98 ± 2.54%), leading to an increased degradation rate. The compressive strength ranged from 10.65 ± 1.90 to 84.93 ± 9.93 MPa, which is directly proportional to the compressive strength of cancellous bone (2–12 MPa). The wettability, water uptake, and biodegradability of PCL scaffolds considerably improved as the amount of NC increased. The results of the cellular assays exhibited increased proliferation, viability, and adhesion of MG-63 cells due to the addition of NHA and NC to the scaffolds. Finally, according to the in vitro results, it can be concluded that 3D-printed samples with higher amounts of NC can be regarded as a suitable scaffold for expediting the regeneration process of bone defects. |
| Anahtar Kelimeler |
| 3D printing | Bone tissue engineering | Hydroxyapatite | Nanoclay | Polycaprolactone |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |
| Scopus | 1 |