Vaccine Design from the Microtubules Role in Coronavirus Entry and Exit: A Molecular Dynamic and Docking Simulation
Yazarlar (2)
Farnoush Naghsh
Islamic Azad University, Science And Research Branch, İran
Islamic Azad University, Science And Research Branch, İran
Prof. Dr. Majıd MONAJJEMI Islamic Azad University, Central Tehran Branch, İran
| Makale Türü |
Özgün Makale
(ESCI dergilerinde yayınlanan tam makale)
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| Dergi Adı | Biointerface Research in Applied Chemistry | ||
| Dergi ISSN | 2069-5837 Wos Dergi Scopus Dergi | ||
| Makale Dili | İngilizce | Basım Tarihi | 10-2022 |
| Cilt / Sayı / Sayfa | 12 / 5 / 6066–6077 | DOI | 10.33263/BRIAC125.60666077 |
| Özet |
| The accurate assembling of microtubules identifies microtubular filaments for a coronavirus that directs the site of viral. By this work, we are able to design a peptide-based multi-epitope vaccine from the surface glycoprotein inside the microtubules via molecular dynamic and docking simulation. Therefore, cell-mediated immunity can be killing the viral particles of the coronavirus. Predicted epitopes were merged using appropriate linkers to increase the immunogenicity of the vaccine. A wide range of bioinformatics analyses was accomplished based on published biological protein sequences in this study. Using molecular docking technology of Discovery-Studio 201673, the receptor-ligand docking of viral proteins with human heme (or porphyrins) was simulated. |
| Anahtar Kelimeler |
| Coronavirus | Microtubules | Vaccine design |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |
| Scopus | 1 |