Preparation and characterization of vancomycin-loaded chitosan/PVA/PEG hydrogels for wound dressing
Yazarlar (5)
Mitra Naeimi
Islamic Azad University, Central Tehran Branch, İran
Islamic Azad University, Central Tehran Branch, İran
Ramtin Tajedin Islamic Azad University, Central Tehran Branch, İran
Farmehr Farahmandfar Islamic Azad University, Central Tehran Branch, İran
Maryam Naeimi Amirkabir University Of Technology, İran
Prof. Dr. Majıd MONAJJEMI Islamic Azad University, Central Tehran Branch, İran
| Makale Türü |
Özgün Makale
(ESCI dergilerinde yayınlanan tam makale)
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| Dergi Adı | Materials Research Express | ||
| Dergi ISSN | 2053-1591 Wos Dergi Scopus Dergi | ||
| Makale Dili | İngilizce | Basım Tarihi | 09-2020 |
| Cilt / Sayı / Sayfa | 7 / 9 / – | DOI | 10.1088/2053-1591/abb154 |
| Özet |
| This study describes a drug-loaded porous hydrogel for delivery of vancomycin. Hydrogels based on chitosan (CS), Polyvinyl alcohol (PVA) and Polyethylene glycol (PEG) were prepared by lyophilization. Scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and fourier transform infrared (FTIR) spectroscopy were used to characterize the structures. Water uptake percentage and vancomycin release were also measured. The antibacterial activity against Staphylococcus aureus was investigated. According to the results, mean pore diameter (MPD) was decreased by addition of PEG and reached to 1.3 ± 0.5 μm. On the other hand, 43% decrease in water content of the hydrogels showed along with the incorporation of PEG. The inhibition zone confirmed antibacterial effect of the vancomycin-loaded hydrogels. The porous CS/PVA/PEG hydrogels containing vancomycin could be good candidates to potentially be used as wound dressing. |
| Anahtar Kelimeler |
| Antibacterial | Hydrogel | Porous |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 47 |
| Scopus | 48 |