Gamma cyclodexterin & Prontosil antibiotic as a bio interface structure for drug delivery systems: a UV sensor (via QM/MM)
Yazarlar (2)
Maryam Derakhshandeh Islamic Azad University, Science And Research Branch, İran
Prof. Dr. Majıd MONAJJEMI Islamic Azad University, Central Tehran Branch, İran
| Makale Türü | Özgün Makale (ESCI dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Biointerface Research in Applied Chemistry | ||
| Dergi ISSN | 2069-5837 Wos Dergi Scopus Dergi | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2018 |
| Cilt / Sayı / Sayfa | 8 / 6 / 3770–3775 | DOI | – |
| Makale Linki | http://www.scopus.com/inward/record.url?eid=2-s2.0-85058700807&partnerID=MN8TOARS | ||
| Özet |
| An approach has been accomplished to a structurally simpler photo-switch machine of prontosil antibacterial drug molecule with gamma cyclodexterin as rot-axon machine. In this system, upon to UV light the stable Trans structure is changed into the unstable of Cis configuration thermodynamically, while the opposite reaction can be operated with visible light. By this work, sulfamidochrysoidine (prontosil) with gamma cyclodexterin ( CD) are simulated as an axle and a wheel respectively, while the boron nitride sheet (BNS) is used as a stopper. Prontosil into CD and combination with BNS can be used such a non-covalent system for photo-isomer-controlled machine. It has been exhibited a new system of molecular motor which works like a hinge motion, and has introduced as light-driven molecular hinges. The CD ring in the system can be reversibly switched through irradiation of wide range of UV and visible lights. This system can be applied for drug delivery of those antibiotics which cannot be used through straight injection. |
| Anahtar Kelimeler |
| h-BN | Molecular motor | Prontosil antibacterial | Rotaxane | Switchable sensor |
