Thermodynamic Study on the Interaction of Copper Ion with Human Growth Hormone
Yazarlar (5)
G. Rezaei Behbehani
Imam Khomeini International University, İran
Imam Khomeini International University, İran
E. Tazikeh Islamic Azad University, Science And Research Branch, İran
A. A. Saboury University Of Tehran, İran
A. Divsalar University Of Tehran, İran
Prof. Dr. Majıd MONAJJEMI Islamic Azad University, Science And Research Branch, İran
| Makale Türü | Özgün Makale (ESCI dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Solution Chemistry | ||
| Dergi ISSN | 0095-9782 Wos Dergi Scopus Dergi | ||
| Makale Dili | İngilizce | Basım Tarihi | 02-2010 |
| Cilt / Sayı / Sayfa | 39 / 2 / 153–164 | DOI | 10.1007/s10953-010-9498-9 |
| Makale Linki | http://www.scopus.com/inward/record.url?eid=2-s2.0-77952425330&partnerID=MN8TOARS | ||
| Özet |
| A thermodynamic study on the interaction between the Cu2+ ion and human growth hormone (hGH) was studied at the temperatures 300.15 and 310.15 K in NaCl solution using isothermal titration calorimetry. The new solvation model was used to reproduce the enthalpies of Cu2++hGH interaction over the whole range of Cu2+ concentrations. It was found that there is a set of three identical and non-interacting binding sites for Cu 2+ ions. The intrinsic dissociation equilibrium constant and the molar enthalpy of binding are 1313.4 μmol · L-1 and -16.80 kJ?mol-1 at 300.15 K, and 1648.2 μmol?L-1 and -16.40 kJ?mol-1 and 310.15 K, respectively. The binding parameters recovered from the new equation are attributed to a structural change of hGH and its biological activity due to metal ion interaction. © 2010 Springer Science+Business Media, LLC. |
| Anahtar Kelimeler |
| Human growth hormone (hGH) | Isothermal titration calorimetry | Solvation model |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 4 |
| Scopus | 4 |