Design of fMet-tRNA and Calculation of its Bonding Properties by Quantum Mechanics
Yazarlar (3)
Prof. Dr. Majıd MONAJJEMI Islamic Azad University, Science And Research Branch, İran
M. Noei
Islamic Azad University, Science And Research Branch, İran
Islamic Azad University, Science And Research Branch, İran
Dr. Öğr. Üyesi Fatemeh MOLLAAMIN Islamic Azad University, Science And Research Branch, İran
| Makale Türü | Özgün Makale (ESCI dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Nucleosides Nucleotides and Nucleic Acids | ||
| Dergi ISSN | 1525-7770 Wos Dergi Scopus Dergi | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2010 |
| Cilt / Sayı / Sayfa | 29 / 9 / 676–683 | DOI | 10.1080/15257771003781642 |
| Makale Linki | http://www.scopus.com/inward/record.url?eid=2-s2.0-77955603290&partnerID=MN8TOARS | ||
| Özet |
| It is generally accepted that initiation of protein synthesis in Escherichia coli starts with formyl-methionine, directed by the codons of AUG or GUG. In one case, reinitiating on the mRNA of amber mutants of UUG is used as the initiation codon. Early studies indeed showed that the triplets AUG, GUG, and UUG are the most effective in stimulating fMet-tRNA binding to ribosomes in vitro. We study the bonding properties of fMet-tRNA. The structure was optimized at the Hartree-Fock (HF) level of theory. We performed nonempirical quantum mechanical calculations at the HF and BLYP and B3LYP/3-21G, 6-31G, and 6-31G* levels of theory in the gas phase and water solvent at temperature of 310 K. Finally, we employed the density functional theory (DFT) and HF to calculate nuclear magnetic resonance spectra and infrared spectra. © Taylor and Francis Group, LLC. |
| Anahtar Kelimeler |
| density functional theory (DFT) | Formyl methionine-tRNA (fMet-tRNA) | Hartree-Fock (HF) |
Science Direct
Design of fMet-tRNA and Calculation of its Bonding Properties by Quantum Mechanics
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 31 |
| Scopus | 71 |