Carbon nanotubes as the specific drug delivery for sulfonamides antibiotics: Instead of injection
Yazarlar (1)
Prof. Dr. Majıd MONAJJEMI Islamic Azad University, Science And Research Branch, İran
| Makale Türü | Özgün Makale (Uluslararası alan indekslerindeki dergilerde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Computational and Theoretical Nanoscience | ||
| Dergi ISSN | 1546-1955 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | |||
| Makale Dili | İngilizce | Basım Tarihi | 01-2015 |
| Cilt / Sayı / Sayfa | 12 / 10 / 3808–3816 | DOI | 10.1166/jctn.2015.4286 |
| Makale Linki | http://www.scopus.com/inward/record.url?eid=2-s2.0-84960154121&partnerID=MN8TOARS | ||
| Özet |
| Sulfonamides were the first antimicrobial to be developed and their discovery laid the foundation for many of the concepts and techniques used in modern drug discovery. Sulfonamide-based compounds were extensively used for antibacterial agents and are the second antimicrobial agents. Moreover, Antibiotics are widely used in human and veterinary medicine for the prevention and treatment of bacterial infectious diseases. An important but often disregarded aspect of antibiotic use is the fate of antibiotic residues entering the environment. The investigation of sulfonamides intra single-walled carbon nanotube (SWCNT) has been studied by theoretical methods. It has been established the best structural and functional of sulfonamide. A number of computational chemistry studies carried out to understand the conformational preferences that may be attributed to stereo electronic effects. These results show the minimized structure of sulfonamide intra SWCNT, calculated potential energy for important dihedral angles, and the effect of temperature on geometry of optimized structure. However, the sulfonamide-SWCNT compound has been displayed different spectrum of gas phase and solvent NMR by GIAO approximation, which appears the results of the determination of the number of active sites in sulfonamide-SWCNT that has the most shifting at indicated model. This model provides an atomistic analysis of the sulfonamide-SWCNT strategy and its implications for further investigations of drugs. |
| Anahtar Kelimeler |
| CNTs | DFT | Drug Discovery | HF | NMR | Sulfonamide |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 25 |