Diabetic Nephropathy and the Relationship between Diabetic Nephropathy and Genetic Polymorphisms
Yazarlar (4)
Fadwa Abdelgader Elmıar
Prof. Dr. Ergin Murat ALTUNER Kastamonu Üniversitesi, Türkiye
Doç. Dr. Asuman ÖZGÖZ Kastamonu Üniversitesi, Türkiye
Prof. Dr. Serap Demir Mersin Üniversitesi, Türkiye
| Makale Türü |
Diğer (Teknik, not, yorum, vaka takdimi, editöre mektup, özet, kitap krıtiği,
araştırma notu, bilirkişi raporu ve benzeri)
(Uluslararası alan indekslerindeki dergilerde yayınlanan teknik not,
editöre mektup, tartışma, vaka takdimi ve özet türünden makale)
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| Dergi Adı | Journal of Scientific Research and Reports | ||
| Dergi ISSN | 2320-0227 | ||
| Dergi Tarandığı Indeksler | Index Copernicus | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2018 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 02-06-2018 |
| Cilt / Sayı / Sayfa | 19 / 3 / 1–11 | DOI | 10.9734/JSRR/2018/41371 |
| Makale Linki | http://journalrepository.org/media/journals/JSRR_22/2018/Jun/Altuner1932018JSRR41371.pdf?/download/MjQ5NDlAQHBm.pdf | ||
| UAK Araştırma Alanları |
Biyokimya
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| Özet |
| Aims The aim of this manuscript is to review the pathogenesis of diabetic nephropathy and the relationship between diabetic nephropathy and genetic polymorphisms. Definition Diabetic nephropathy is one of the kidney diseases that progresses to harm the capillaries in the glomeruli of the kidneys. Characterization: Diabetic nephropathy is characterized by diffuse scarring of the glomeruli and nephrotic syndrome. Reason The main reason for diabetic nephropathy is proposed as long-lasting diabetes and in many developed countries it is the main cause of dialysis. Diabetic nephropathy is categorized as one of the microangiopathic complications of diabetes. Several studies present that there is a correlation between diabetic nephropathy and genetic polymorphisms. Conclusion The genetic susceptibility may be an important factor in the development of diabetic nephropathy. Several genes, such as TNF-α, eNOS, GLUT1, ACE, FABP2, ADRB2 and ADIPO with some allelic polymorphisms were proposed to be important in the pathogenesis of diabetic nephropathy. In addition, the angiotensinogen M235T and ANP polymorphisms were proposed to be associated with diabetic nephropathy development, but following studies couldn’t be able to replicate these observations. On contrary to several successful association studies, there are also numerous contradicting observations too. As a result of this, the relationship between diabetic nephropathy and genetic polymorphisms should be studied in detail for different populations. But while conducting such studies the genetic heterogeneity in populations should be taken into account and also the … |
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| Google Scholar | 1 |