Investigation of the Cytotoxic Effect of 2-Amino-4-phenylthiazole Derivative Against MCF-7 and AGS Cancer Cells
Yazarlar (1)
Doç. Dr. İrfan ÇINAR Kastamonu Üniversitesi, Türkiye
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Özgün Makale
(Ulusal alan endekslerinde (TR Dizin, ULAKBİM) yayınlanan tam makale)
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| Dergi Adı | Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi | ||
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| Makale Dili | Türkçe | Basım Tarihi | 04-2025 |
| Cilt / Sayı / Sayfa | 30 / 1 / 61–68 | DOI | 10.53433/yyufbed.1572502 |
| Makale Linki | https://dergipark.org.tr/en/pub/yyufbed/issue/91112/1572502 | ||
| UAK Araştırma Alanları |
Eğitim Bilimleri
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| Özet |
| This study aimed to investigate the cytotoxic effects of 2-amino thiazole compound (3) on MCF-7 breast and AGS gastric cancer cells. We examined the cytotoxic effects of various concentrations (10-25-50-100 μg/mL) of 2-aminothiazol compound (3) on MCF-7 breast cancer and AGS gastric cells at 24, 48 and 72 hours using MTT assay. MTT assays demonstrate that the 2-amino thiazole (3) compound has a time- and dose-dependent inhibitory effect on the proliferation of MCF-7 and AGS cancer cells. Analysis of the data obtained from MTT assay showed that IC50 values for thiazole were 80.13, 71.03 and 59.24 µg/ml and 75.03, 38.12 and 28.01 µg/ml for 24, 48 and 72 hours on MCF-7 and AGS cells, respectively. The 100 μg/mL dose was demonstrated to be most effective on both cancer cells. Our results suggest that the 2-amino-4-phenylthiazole (3) compound has a dose-dependent effect on cytotoxicity in MCF7 breast and AGS gastric cancer cells. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
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| Google Scholar | 1 |