Synthesis and characterization of NIR-sensitive curcumin-gelatin nanoparticles for targeted drug delivery in 3D colon cancer
Yazarlar (3)
Doç. Dr. Dilşad ÖZERKAN Kastamonu Üniversitesi, Türkiye
Doç. Dr. Ferdane Danışman Kalındemirtaş Bilecik Şeyh Edebali Üniversitesi, Türkiye
Prof. Dr. İshak Afşin Kariper Erciyes Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Scientific Reports (Q1) | ||
| Dergi ISSN | 2045-2322 Dergi Bilgileri (2026) | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | Türkçe | Basım Tarihi | 05-2026 |
| Kabul Tarihi | 24-02-2026 | Yayınlanma Tarihi | 05-03-2026 |
| Cilt / Sayı / Sayfa | 16 / 1 / 12167–0 | DOI | 10.1038/s41598-026-42199-3 |
| Makale Linki | https://www.nature.com/articles/s41598-026-42199-3 | ||
| UAK Araştırma Alanları |
Hücre Biyolojisi
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| Özet |
| Curcumin (CUR) exhibits potent anti-cancer effects; however, its poor water solubility limits its clinical use. This study explores gelatin nanoparticles (GelNPs) as nanocarriers to improve curcumin delivery. We aimed to enhance the release and efficacy of photosensitive curcumin-loaded GelNPs (Cur-GelNPs) using infrared (IR) light-induced localized hyperthermia in a 3D co-culture cancer model. Cur-GelNPs were synthesized and characterized via DLS, FTIR, STEM, Raman, HPLC, and DSC. Cytotoxicity, migration, invasion, apoptosis, and drug resistance were assessed using MTT, Transwell, Hoechst/PI staining, and Rho123 assays, respectively. Optimal results were achieved by IR treatment at 38 C for 30 s. Cur-GelNPs localized in the cytoplasm due to curcumin's natural fluorescence. At 25 µg/ml, Cur-GelNPs significantly reduced the viability, invasion, and migration of colon cancer cells, while promoting ... |
| Anahtar Kelimeler |
| Colon cancer 3D model | Curcumin | Gelatin nanoparticles | Infrared light (IR) | Research and development (R&D) |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 2 |