Protective Effect of Tyrosol on Cisplatin–Induced Ovarian Inflammation and Oxidative Stress in Rats.
Yazarlar (1)
Doç. Dr. Gökhan UYANIK Kastamonu Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (Uluslararası alan indekslerindeki dergilerde yayınlanan tam makale) | ||
| Dergi Adı | Revista Cientifica de la Facultade de Veterinaria | ||
| Makale Dili | – | Basım Tarihi | 07-2024 |
| Cilt / Sayı / Sayfa | 34 / 3 / – | DOI | – |
| Makale Linki | https://search.ebscohost.com/login.aspx?direct=true&profile=ehost&scope=site&authtype=crawler&jrnl=07982259&AN=183995583&h=P8I0myUnXW5iP3RYD6B%2FQTpt%2FOI4DUuKp61OLG5a8IbRneL%2BEELOQMt2ykw1n2TDdsVPfYrEaQuEbuSI58hc8Q%3D%3D&crl=c | ||
| Özet |
| Ovarian cancer is a widespread type of cancer among gynecologic cancers and has a very high mortality rate. For this reason, the search for new treatments continues. Tyrosol is a phenolic compound with antioxidant and anti–inflammatory activity. The study, it was investigated the effect of Tyrosol on oxidative stress and inflammatory parameters in cisplatin–induced ovarian inflammation and oxidative stress in rats. For this purpose, twenty–four female Wistar albino rats were divided into four groups: control, Cisplatin, Tyrosol, and Cisplatin+ Tyrosol. Cisplatin was administered intraperitoneally at 6 mg· kg-1 twice, once a week. Tyrosol (20 mg· kg-1) was administered daily by oral gavage for fourteen d. Oxidative stress and inflammatory biomarkers were measured in ovarian tissue. Cisplatin administration increased Malondialdehyde (MDA), tumor necrosis factor alpha (TNF–α), interleukin 6 (IL–6), and interleukin 1 … |
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