| Yazarlar |
Kutaiba Ibrahin Alzand
|
Prof. Dr. Sabri ÜNAL
Kastamonu Üniversitesi, Türkiye |
|
Mansor Boufars
|
| Özet |
| Three new lanostane-type triterpenes (compounds 1–3), 1 new abietane-type diterpene (compound 4), and 10 known compounds (5–14) were isolated from sclerotia of Inonotus obliquus. Their structures were elucidated through a combination of spectrometric techniques, including infrared, 1-dimensional, and 2-dimensional nuclear magnetic resonance and high-resolution electrospray mass spectrometry. In in vitro assays, compounds 2 and 4–12 showed hepatoprotective effects againstd-galactosamine–induced damage in WB-F344 cells, with inhibitory effects from 35.4% to 83.8%. Compounds 3, 13, and 14 exhibited selective cytotoxicity against Bel-7402, A-549, or KB cell lines. Compounds 13 and 14 showed inhibitory effects against protein tyrosine kinases, with half-maximal inhibitory concentrations of 23.8 and 7.4 μmol/L, respectively. |
| Anahtar Kelimeler |
| Bioactive compounds | Inonotus obliquus | Medicinal mushrooms | Terpenes |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS |
| Dergi ISSN | 1521-9437 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2018 |
| Cilt No | 20 |
| Sayı | 6 |
| Sayfalar | 507 / 516 |
| Doi Numarası | 10.1615/IntJMedMushrooms.2018026007 |
| Makale Linki | http://www.dl.begellhouse.com/journals/708ae68d64b17c52,450db401445f9ce7,27285fcf0c202e3e.html |
| Atıf Sayıları | |
| SCOPUS | 6 |
