Beneficial therapeutic effects of sildenafil on bone healing in animals treated with bisphosphonate
Yazarlar (1)
Prof. Dr. İzzet ŞENER Kastamonu Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (Uluslararası alan indekslerindeki dergilerde yayınlanan tam makale) | ||
| Dergi Adı | Nigerian Journal of Clinical Practice | ||
| Makale Dili | – | Basım Tarihi | 02-2018 |
| Cilt / Sayı / Sayfa | 21 / 2 / 217–224 | DOI | – |
| Makale Linki | https://journals.lww.com/njcp/fulltext/2018/21020/Beneficial_Therapeutic_Effects_of_Sildenafil_on.16.aspx | ||
| UAK Araştırma Alanları |
Organik Kimya
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| Özet |
| Objectives:The purpose of the present study was to evaluate the effects of sildenafil on mandibular fracture healing in animals treated with zoledronic acid by using histologic, histomorphometric, immunohistochemical, and radiodensitometric methods.Materials and Methods:A total of 36 Sprague–Dawley rats (3 months old) were used. All animals were treated intraperitoneally with 0.1 mg/kg zoledronate three times per week, for a total of 8 weeks. Postoperatively, the animals were divided into two groups: zoledronate group (Z), which had no treatment applied (n= 18), and zoledronate+ sildenafil (ZS), which were treated daily with 10 mg/kg sildenafil (n= 18). Each group was divided into two subgroups and the animals were sacrificed at the end of week 1 (Z1 and ZS1, n= 9) and week 4 (Z4 and ZS4, n= 9) after the operation. Histologic, histomorphometric, immunohistochemical analysis, and radiodensitometry were … |
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