Cyclopamine Induced Expression of Immune-related Genes in Rainbow trout (Oncorhynchus mykiss) Head Kidney Leukocytes
Yazarlar (4)
Doç. Dr. Adem Yavuz SÖNMEZ Kastamonu Üniversitesi, Türkiye
Dr. Öğr. Üyesi Rahmi Can ÖZDEMİR Kastamonu Üniversitesi, Türkiye
Doç. Dr. Soner BİLEN Kastamonu Üniversitesi, Türkiye
Dr. Öğr. Üyesi Keriman YÜRÜTEN ÖZDEMİR Kastamonu Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Israeli Journal of Aquaculture Bamidgeh (Q4) | ||
| Dergi ISSN | 0792-156X Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2018 |
| Cilt / Sayı / Sayfa | 70 / 1 / 1–8 | DOI | – |
| Makale Linki | https://ija.scholasticahq.com/issue/2842 | ||
| UAK Araştırma Alanları |
Su Ürünleri Yetiştiriciliği
|
||
| Özet |
| This study investigated the effect of cyclopamine, a hedgehog signaling inhibitor, on immune-related gene expression in rainbow trout head kidney leukocytes in vitro. At 1h sampling time COX 2, IFN-2, TNF-á, C3, MHC-II, Il-1â, IL-12, IL-10, and IL-6 increased significantly in groups exposed to cyclopamine at 30 ìg/ml. However, in groups exposed to 10 and 20 ìg/ml cyclopamine, the expression of these genes decreased significantly. At 4h sampling time, levels of COX-2, IFN-1, IFN-2, TNF-á, TGF-â, IgT, and MHC-II in groups exposed to 20 ìg/ml cyclopamine increased. At 8h sampling time, COX2, IFN-Reg, and TNF-á expression in groups exposed to 10 and 30 ìg/ml cyclopamine increased significantly compared to those in the controls. Conversely the expression decreased significantly for almost all other genes. At 12h sampling time, almost all genes increased significantly in groups exposed to 10 ìg/ml cyclopamine … |
| Anahtar Kelimeler |
| Cyclopamine | Gene expression | Immune responses | Leukocyte | Rainbow trout |
