Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Integration of Enrofloxacin Following Single Oral Administration of Different Doses in Brown Trout (Salmo trutta)

Üney, Kamil; TERZİ, Ertuğrul; Çorum, Duygu Durna; ÖZDEMİR, Rahmi Can; BİLEN, Soner; Çorum, Orhan

doi:10.3390/ani11113086

Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Integration of Enrofloxacin Following Single Oral Administration of Different Doses in Brown Trout (Salmo trutta)

Yazarlar (6)

Prof. Dr. Kamil Üney Selçuk Üniversitesi, Türkiye

Doç. Dr. Ertuğrul TERZİ Kastamonu Üniversitesi, Türkiye

Doç. Dr. Duygu Durna Çorum Kastamonu Üniversitesi, Türkiye

Dr. Öğr. Üyesi Rahmi Can ÖZDEMİR Kastamonu Üniversitesi, Türkiye

Doç. Dr. Soner BİLEN Kastamonu Üniversitesi, Türkiye

Prof. Dr. Orhan Çorum Kastamonu Üniversitesi, Türkiye

Makale Türü	Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı	Animals (Q1)
Dergi ISSN	2076-2615 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler	SCI-Expanded
Makale Dili	İngilizce	Basım Tarihi	01-2021
Kabul Tarihi	–	Yayınlanma Tarihi	28-10-2021
Cilt / Sayı / Sayfa	11 / 11 / 3086–0	DOI	10.3390/ani11113086
Makale Linki	http://dx.doi.org/10.3390/ani11113086
UAK Araştırma Alanları	Su Ürünleri Yetiştiriciliği Su Ürünleri Hastalıkları

Özet

The pharmacokinetic of enrofloxacin was investigated in brown trout (Salmo trutta) following oral administration of 10, 20, and 40 mg/kg doses at 11 ± 1.5 °C. Furthermore, MICs of enrofloxacin against Aeromonas hydrophila and A. sobria were determined. The plasma concentrations of enrofloxacin and ciprofloxacin were determined using HPLC–UV and analyzed by non-compartmental method. Following oral administration at dose of 10 mg/kg, total clearance (CL/F), area under the concentration–time curve (AUC0−∞) and peak plasma concentrations (Cmax) were 41.32 mL/h/kg, 242.02 h*μg/mL and 4.63 μg/mL, respectively. When compared to 10 mg/kg dose, the dose-normalized AUC0–∞ and Cmax were increased by 56.30% and 30.08%, respectively, while CL/F decreased by 38.4% at 40 mg/kg dose, suggesting the non-linearity. Ciprofloxacin was not detected in the all of plasma samples. The MIC values of enrofloxacin were ranged 0.0625–4 μg/mL for A. hydrophila and 0.0625–2 μg/mL for A. sobria. The oral administration of enrofloxacin at 10 (for 192 h) and 20 (for 240 h) mg/kg doses provided the AUC of enrofloxacin equal to 1.23 and 1.96-fold MICs, respectively, for A. hydrophila and A. sobria with the MIC90 values of 1 µg/mL. However, further researches are needed on the PK/PD study of enrofloxacin for the successful treatment of infections caused by A. hydrophila and A. sobria in brown trout.

Anahtar Kelimeler

Brown trout | Enrofloxacin | Pharmacodynamics | Pharmacokinetics

BM Sürdürülebilir Kalkınma Amaçları

Atıf Sayıları
Web of Science	25
Scopus	30
Google Scholar	43

Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Integration of Enrofloxacin Following Single Oral Administration of Different Doses in Brown Trout (Salmo trutta)

Dergi Adı	Animals
Yayıncı	Multidisciplinary Digital Publishing Institute (MDPI)
Açık Erişim	Evet
ISSN	2076-2615
E-ISSN	2076-2615
CiteScore	5,2
SJR	0,733
SNIP	1,085

Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Integration of Enrofloxacin Following Single Oral Administration of Different Doses in Brown Trout (Salmo trutta)

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