Importance of TRPV1 cation channel on molecular pathways of pain.
Yazarlar (3)
| Makale Türü | Özgün Makale (Uluslararası alan indekslerindeki dergilerde yayınlanan tam makale) | ||
| Dergi Adı | |||
| Makale Dili | – | Basım Tarihi | 04-2016 |
| Cilt / Sayı / Sayfa | 21 / 1 / 1–10 | DOI | 10.5555/20163134891 |
| Makale Linki | https://www.cabidigitallibrary.org/doi/full/10.5555/20163134891 | ||
| UAK Araştırma Alanları |
Sosyal, Beşeri ve İdari Bilimler
|
||
| Özet |
| TRPV1 is a non-selective cation channel that is mostly located on central and primary afferent sensory neurons. TRPV1 is activated by noxious painful stimuli such as acid (low pH), noxious heat (>430C), voltage, components of the inflammatory, oxidative stress and vanilloids. TRPV1 has important role on detection and transmission of painful stimuli. In this review article, the authors summarize the recent information of pain literature to understand the etiology of the pain. The effects of TRPV1 on different types of neuronal pain are investigated in the laboratory and clinical trials. TRPV1 is reported to contribute to acute, chronic pain, such as osteoarthritis, neuropathic pain, migraine, bone cancer pain. It is also reported that TRPV1 takes part in pain processing and modulation, thermoregulation, osmoregulation among other functions. Activation of TRPV1 has important role on persistent cough, chronic obstructive … |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 1 |