Anti-inflammatory and antioxidant properties of jervine, a sterodial alkaloid from rhizomes of Veratrum album
Yazarlar (9)
Fadime Dumlu Kafkas Üniversitesi, Türkiye
Prof. Dr. Tuba Aydın Ağrı İbrahim Çeçen Üniversitesi, Türkiye
Fehmi Odabaşoğlu Kafkas Üniversitesi, Türkiye
Doç. Dr. Özlem Aydın Berktaş Giresun Üniversitesi, Türkiye
Doç. Dr. Zerrin Kutlu Atatürk Üniversitesi, Türkiye
Doç. Dr. Hüseyin Serkan Erol Kastamonu Üniversitesi, Türkiye
Prof. Dr. Mesut Bünyami Halıcı Atatürk Üniversitesi, Türkiye
Prof. Dr. Elif Çadırcı Atatürk Üniversitesi, Türkiye
Prof. Dr. Ahmet Çakır Kilis 7 Aralık Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | PHYTOMEDICINE (Q1) | ||
| Dergi ISSN | 0944-7113 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2019 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-03-2019 |
| Cilt / Sayı / Sayfa | 55 / 2019 / 191–199 | DOI | 10.1016/j.phymed.2018.06.035 |
| Makale Linki | https://hdl.handle.net/20.500.12501/699 | ||
| UAK Araştırma Alanları |
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| Özet |
| Background: Veratrum, hellebore is an important plant species of the Liliaceae family and jervine is the characteristic steroidal alkaloid constituent of Veratrum album. Purpose: In the current study, anti-inflammatory and antioxidant effects of jervine isolated from NH 4 OH-benzene extract of V. album rhizomes were investigated on CAR induced paw edema in rats. Methods/Study design: In inflammatory study, 50, 100, 200 and 400 mg/kg doses of jervine, 25 mg/kg doses of DIC and IND were orally administered, and the volume of the foots were measured up to their knee arthrosis by plethismometer. After one hour of the oral administration of the all treatments, 0.1 ml of CAR solution (1%) was injected into the foot of the all rat groups and the volume of the foots were measured during 5 h after CAR injection. GPx, SOD, GR, MPO, CAT enzymes activities and GSH, LPO levels of the supernatants of paw homogenates and inflammation biomarkers such as TNF-α and IL-1β in the rats serums were also estimated. Results: According to the present results, jervine exerted 50.4–73.5% anti-inflammatory effects in carrageenan induced paw edema. Inflammation biomarkers such as TNF-α, IL-1β and MPO that increased by CAR injection were suppressed by the administrations of all doses of jervine, IND and DIC. In all paw tissues, LPO levels as indicator of oxidative tissue damage were found to be high in CAR-treated group and it was found to be decreased in all doses of jervine. Conclusion: Jervine, DIC and IND reduced the negative effects of CAR due to increasing effects on the SOD, CAT, GSH, GPx and GR antioxidants. |
| Anahtar Kelimeler |
| Acute inflammation | Antioxidants | Carrageenan | Jervine | Veratrum album |
BM Sürdürülebilir Kalkınma Amaçları
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