| Yazarlar |
Kübra Koç
Atatürk Üniversitesi, Türkiye |
|
Nihal Şimşek Özek
Atatürk Üniversitesi, Türkiye |
|
Ferhunde Aysin
Türkiye |
|
Özlem Demir
Türkiye |
|
Aslı Yılmaz
Türkiye |
|
Mehmet Yılmaz
Türkiye |
|
Fatime Geyikoğlu
Atatürk Üniversitesi, Türkiye |
Doç. Dr. Hüseyin Serkan EROL
Kastamonu Üniversitesi, Türkiye |
| Özet |
| This study investigates the protective role of Hispidulin on acute respiratory distress syndrome (ARDS) in rats. Rats were divided into three groups: control, ARDS, ARDS+ Hispidulin. The ARDS models were established by injecting rats with oleic acid. Hispidulin (100 mg/kg) was injected i.p. an hour before ARDS. Myeloperoxidase (MPO), Interleukin-8 (IL-8), Mitogen-activated protein kinases (MAPK), Lipid Peroxidation (LPO), Superoxide Dismutase (SOD), Glutathione (GSH), and Angiotensin-converting enzyme (ACE) were determined by ELISA. Tumor necrosis factor-alpha (TNF-α) expression was described by RT-qPCR. Caspase-3 immunostaining was performed to evaluate apoptosis. Compared with the model group, a significant decrease was observed in the MPO, IL-8, MAPK, ACE, LPO levels, and TNF-α expression in the ARDS+ Hispidulin group. Moreover, reduced caspase-3 immunoreactivity and activity of ACE were detected in the Hispidulin+ARDS group. The protective effect of Hispidulin treatment may act through inhibition of the ACE activity and then regulation of inflammatory cytokine level and alteration of apoptosis. |
| Anahtar Kelimeler |
| ACE activity | Hispidulin | lung injury with ARDS |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH |
| Dergi ISSN | 0960-3123 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 02-2024 |
| Cilt No | 34 |
| Sayı | 2 |
| Sayfalar | 755 / 766 |
| Doi Numarası | 10.1080/09603123.2023.2166023 |
| Makale Linki | http://dx.doi.org/10.1080/09603123.2023.2166023 |
| Atıf Sayıları |
