Hispidulin exerts a protective effect against oleic acid induced-ARDS in the rat via inhibition of ACE activity and MAPK pathway
Yazarlar (8)
Doç. Dr. Kübra Koç Atatürk Üniversitesi, Türkiye
Doç. Dr. Nihal Şimşek Özek Atatürk Üniversitesi, Türkiye
Ferhunde Aysin Türkiye
Özlem Demir Türkiye
Aslı Yılmaz Türkiye
Mehmet Yılmaz Türkiye
Prof. Dr. Fatime Geyikoğlu Atatürk Üniversitesi, Türkiye
Doç. Dr. Hüseyin Serkan Erol Kastamonu Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | International Journal of Environmental Health Research (Q3) | ||
| Dergi ISSN | 0960-3123 Dergi Bilgileri (2024) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2024 |
| Kabul Tarihi | 02-01-2023 | Yayınlanma Tarihi | 09-01-2023 |
| Cilt / Sayı / Sayfa | 34 / 2 / 755–766 | DOI | 10.1080/09603123.2023.2166023 |
| Makale Linki | http://dx.doi.org/10.1080/09603123.2023.2166023 | ||
| UAK Araştırma Alanları |
Hücre Biyolojisi
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| Özet |
| This study investigates the protective role of Hispidulin on acute respiratory distress syndrome (ARDS) in rats. Rats were divided into three groups: control, ARDS, ARDS+ Hispidulin. The ARDS models were established by injecting rats with oleic acid. Hispidulin (100 mg/kg) was injected i.p. an hour before ARDS. Myeloperoxidase (MPO), Interleukin-8 (IL-8), Mitogen-activated protein kinases (MAPK), Lipid Peroxidation (LPO), Superoxide Dismutase (SOD), Glutathione (GSH), and Angiotensin-converting enzyme (ACE) were determined by ELISA. Tumor necrosis factor-alpha (TNF-α) expression was described by RT-qPCR. Caspase-3 immunostaining was performed to evaluate apoptosis. Compared with the model group, a significant decrease was observed in the MPO, IL-8, MAPK, ACE, LPO levels, and TNF-α expression in the ARDS+ Hispidulin group. Moreover, reduced caspase-3 immunoreactivity and activity of ACE were detected in the Hispidulin+ARDS group. The protective effect of Hispidulin treatment may act through inhibition of the ACE activity and then regulation of inflammatory cytokine level and alteration of apoptosis. |
| Anahtar Kelimeler |
| ACE activity | Hispidulin | lung injury with ARDS |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |