| Yazarlar |
Mohammad Alhılal
Mardin Artuklu Üniversitesi, Türkiye |
Doç. Dr. Hüseyin Serkan EROL
Türkiye |
|
Serkan Yıldırım
Türkiye |
|
Ahmet Çakır
Türkiye |
|
Murat Koç
Türkiye |
|
Demet Çelebi
Türkiye |
|
Mesut Bünyami Halıcı
Atatürk Üniversitesi, Türkiye |
| Özet |
| This paper aimed to examine the impact of flavonoid osajin (OSJ) on liver damage induced by sepsis. A total of 30 male rats were divided into 5 groups (Sham, sepsis, OSJ 150, OSJ 300 and reference). During sepsis, elevated lipid peroxidation (LPO) level and catalase activity (CAT) and decreased glutathione (GSH) level and superoxide dismutase (SOD) activity were observed in hepatic tissues of sepsis group in comparison with Sham group. A strong interleukin-33 and caspase-3 expressions were detected in hepatic tissues of sepsis group. On the contrary, OSJ administration to OSJ 300 group showed a significant decrease (P < 0.001) in LPO level (176±2.926) and significant increase (P < 0.001) in GSH level (10.586±0.083) and SOD activity (29.152±0.094) in comparison with sepsis group (185.777±1.735, 8.246±0.124, 24.307±0.379 respectively). In addition, the consumption of OSJ reduced expressions of interleukin-33 and caspase-3 and improved histopathological integrity. In conclusions, OSJ has hepatoprotective effect against sepsis-induced liver injury. |
| Anahtar Kelimeler |
| Liver | osajin | oxidative stress | sepsis |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Journal of Taibah University for Science |
| Dergi ISSN | 1658-3655 |
| Dergi Tarandığı Indeksler | SCI-Exp, SCOPUS, Curation, Current Contents Physical Chemical & Earth Sciences, Essential Science Indicators, Reference Master, Sophia |
| Dergi Grubu | Q1 |
| Makale Dili | Türkçe |
| Basım Tarihi | 04-2023 |
| Cilt No | 17 |
| Sayı | 1 |
| Sayfalar | 2201250 / 2201250 |
| Doi Numarası | 10.1080/16583655.2023.2201250 |
| Makale Linki | http://dx.doi.org/10.1080/16583655.2023.2201250 |
| Atıf Sayıları | |
| WoS | 2 |
| SCOPUS | 2 |
| Google Scholar | 2 |
