Liposomes encapsulating catechins: a biophysical approach for skin cancer therapy
Yazarlar (1)
| Makale Türü | Özgün Makale (Uluslararası alan indekslerindeki dergilerde yayınlanan tam makale) | ||
| Dergi Adı | PQDT-Global | ||
| Makale Dili | – | Basım Tarihi | 01-2019 |
| Makale Linki | https://search.proquest.com/openview/ef567ca0d02de67ebc996e7cfea2f761/1?pq-origsite=gscholar&cbl=51922&diss=y | ||
| UAK Araştırma Alanları |
Fiziksel Kimya
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| Özet |
| Every year, a large number of skin cancer cases caused by a prolonged ultraviolet radiation exposure, are diagnosed around the world. Epigallocatechin-3-gallate (EGCG) derived from green tea leaves, display protective effect against oxidative stress which reduce the risk of contracting skin cancer. However, frequently, the antioxidant and anti-inflammatory activities of EGCG in are compromised because this molecule is extremely unstable and rapidly degraded in physiological conditions. Considering these issues, the main goal of this thesis was developed a stable liposomal nanocarrier for topical/transdermal delivery of EGCG, firstly, to increase its bioavailability and, secondly, to offer an desirable skin protection against harmful effects of UV radiation. Primarily, the molecular mechanisms between EGCG and different phospholipids were studied using Langmuir experiments, revealling the affinity and localization … |
| Anahtar Kelimeler |
