Evaluation of 8-hydroxy-2-deoxyguanosine and NFkB activation oxidative stress response acetylcholinesterase activity and histopathological changes in rainbow trout brain exposed to linuron
Yazarlar (5)
Prof. Dr. Ahmet Topal Atatürk Üniversitesi, Türkiye
Prof. Dr. Gonca Alak Atatürk Üniversitesi, Türkiye
Serdar Altun Atatürk Üniversitesi, Türkiye
Doç. Dr. Hüseyin Serkan Erol Atatürk Üniversitesi, Türkiye
Muhammed Atamanalp Atatürk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | ||
| Dergi ISSN | 1382-6689 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2017 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-01-2017 |
| Cilt / Sayı / Sayfa | 49 / 1 / 14–20 | DOI | 10.1016/j.etap.2016.11.009 |
| Makale Linki | http://linkinghub.elsevier.com/retrieve/pii/S1382668916302976 | ||
| UAK Araştırma Alanları |
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| Özet |
| Linuron is a widely used herbicide to control grasses and annual broad leaf weeds. It is known that linuron has toxic effects on different organisms. However, the toxic effects of linuron on aquatic organisms, especially fish, is completely unknown. Thus, we aimed to investigate changes in 8-hydroxy-2-deoxyguanosine (8-OHdG) and nuclear factor kappa B (NFkB) activity, histopathological changes, antioxidant responses and acetylcholinesterase (AChE) activity in rainbow trout brain after exposure to linuron. Fish were exposed to 30 μg/L, 120 μg/L and 240 μg/L concentrations of linuron for twenty-one days. Brain tissues were taken from fish for 8-OHdG and NFkB activity, histopathological examination and determination of superoxide dismutase (SOD), catalase (CAT) enzyme activity, lipid peroxidation (LPO), and reduced glutathione (GSH) levels. Our data indicated that high linuron concentrations caused a decrease in GSH levels, SOD and CAT activities in brain tissues (p < 0.05). LPO levels were significantly increased by 240 μg/L linuron. All concentrations caused a significant inhibition in brain AChE enzyme activity (p < 0.05). Immunopositivity was detected for 8-OHdG and NFkB, and linuron exposure caused histopathological damage to the brain tissues. The results of this study can provide useful information for understanding of linuron-induced toxicity. |
| Anahtar Kelimeler |
| 8-hydroxy-2-deoxyguanosine | AChE | Fish | Histopathology | Linuron | NFkB | Oxidative stress | Pesticide | Toxicity |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |