| Yazarlar |
Didem Onk
Erzincan Binali Yıldırım Üniversitesi, Türkiye |
|
Oruç Alper Onk
Erzincan Binali Yıldırım Üniversitesi, Türkiye |
|
Kültigin Türkmen
Necmettin Erbakan Üniversitesi, Türkiye |
Doç. Dr. Hüseyin Serkan EROL
Atatürk Üniversitesi, Türkiye |
|
Tülin Akarsu Ayazoğlu
|
|
Osman Nuri Keleş
Atatürk Üniversitesi, Türkiye |
|
Mesut Bünyami Halıcı
Atatürk Üniversitesi, Türkiye |
|
Ergün Topal
|
| Özet |
| Background. Inflammation and oxidative stress (OxS) contribute to the pathogenesis of diabetic kidney disease (DKD) and contrast-induced nephropathy (CIN). Patients with DKD were found to be more prone to CIN. Interleukin-33 (IL-33) is a proinflammatory cytokine, but its role in DKD and CIN is unknown. Methods. Thirty male Sprague-Dawley rats were enrolled. The first group was comprised of healthy rats (HRs), whereas the other four groups were made up of diabetic rats (DRs), diabetic rats with contrast-induced nephropathy (CIN + DRs), melatonin-treated diabetic rats (MTDRs), and melatonin-treated CIN + DRs (MTCIN + DRs). All groups except the HRs received 50 mg/kg/day streptozotocin (STZ). CIN + DRs were constituted by administrating 1.5 mg/kg of intravenous radiocontrast dye on the 35th day. MTDRs and MTCIN + DRs were given 20 mg/kg/day of intraperitoneal injection of melatonin (MT) from the 28th day for the constitutive seven days. Results. We observed increased IL-33 in the kidney tissue following induction of CIN in DRs. To determine whether MT is effective in preventing CIN, we administered MT in CIN + DRs and demonstrated that kidney tissue levels of OxS markers, inflammatory cytokines, and IL-33 were significantly diminished in MTCIN + DRs compared with other groups without MT treatment (p<0.05). Conclusion. Inhibition of IL-33 with MT provides therapeutic potential in DKD with CIN. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | MEDIATORS OF INFLAMMATION |
| Dergi ISSN | 0962-9351 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2016 |
| Cilt No | 2016 |
| Sayı | 1 |
| Sayfalar | 1 / 10 |
| Doi Numarası | 10.1155/2016/9050828 |
| Makale Linki | http://www.hindawi.com/journals/mi/2016/9050828/ |
| Atıf Sayıları | |
| WoS | 40 |
| SCOPUS | 46 |
| Google Scholar | 59 |
