| Yazarlar |
Didem Onk
Erzincan Üniversitesi, Türkiye |
|
Oruç Alper Onk
Erzincan Üniversitesi, Türkiye |
Doç. Dr. Hüseyin Serkan EROL
Atatürk Üniversitesi, Türkiye |
|
Mustafa Özkaraca
Atatürk Üniversitesi, Türkiye |
|
Selim Çomaklı
Atatürk Üniversitesi, Türkiye |
|
Tülin Akarsu Ayazoğlu
|
|
Ufuk Kuyrukluyıldız
Erzincan Üniversitesi, Türkiye |
|
Süheyla Ünver
Erzincan Üniversitesi, Türkiye |
| Özet |
| Purpose: To investigate the effects of melatonin on antioxidant capacity, inflammation and apoptotic cell death (through expression of cleaved-caspase 3) in lung tissue samples of diabetic rats.Methods: Thirty male Sprague-Dawley rats were randomly divided into three groups.Group 1 (control group) was made up of healthy rats.Group 2 (diabetes group) received streptozotocin at a dose of 50 mg/kg/day for 5 days.Group 3 (diabetes plus melatonin group) received streptozotocin at a dose of 50 mg/kg/day for 5 days and then they received melatonin at a dose of 20 mg/kg/day between 28thand 35thdays of the study.Results: Tissue MDA and MPO levels were found to be significantly higher in diabetes group compared to control group (p<0.05) whilst administration of melatonin was found to significantly lower this increase down to normal levels (p<0.05).Bronchus associated lymphoid tissue (BALT) was more severe in diabetics whereas administration of melatonin alleviated this hyperplasia.Cleaved caspase 3 activity was severe in hyperplastic BALT in diabetic rats however in lowered down to moderate level when melatonin was administered.Conclusion: The melatonin caused an increase in antioxidant capacity and decreased the expression of cleaved-caspase 3. |
| Anahtar Kelimeler |
| Lung | Melatonin | Rats |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Acta Cirurgica Brasileira |
| Dergi ISSN | 0102-8650 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 04-2018 |
| Cilt No | 33 |
| Sayı | 4 |
| Sayfalar | 375 / 385 |
| Doi Numarası | 10.1590/s0102-865020180040000009 |
| Makale Linki | http://www.scielo.br/scielo.php?script=sci_arttextpid=S0102-86502018000400375lng=entlng=en |
| Atıf Sayıları | |
| WoS | 20 |
| SCOPUS | 18 |
| Google Scholar | 34 |
