| Yazarlar |
Aliseydi Bozkurt
Türkiye |
|
Harun Budak
Türkiye |
Doç. Dr. Hüseyin Serkan EROL
Türkiye |
|
Serpil Can
Türkiye |
|
Tolga Mercantepe
Türkiye |
|
Yiğit Akın
Türkiye |
|
İsa Özbey
Türkiye |
|
Murat Çankaya
Türkiye |
|
Mesut Bünyami Halıcı
Türkiye |
|
Taha Abdulkadir Çoban
Türkiye |
| Özet |
| Cystitis is defined as an inflammation of the bladder caused by a bacterial infection, and it can be dangerous and painful when it spreads through the internal organs. In this study, antioxidant effects of hydroxylfasudil (HF) at the enzymatic and molecular level on kidney and liver tissues in cystitis rat model, which is caused by inflammation of the rat bladder with a protamine sulphate (PS), was examined. Quantitative changes of reduced glutathione (GSH) and lipid peroxidation (LPO) levels, which are a marker for oxidative stress, were determined in rat kidney and liver tissues for each groups. And then molecular and biochemical impact of HF treatment on antioxidant enzymes including superoxide dismutase (SOD) and catalase (CAT) in cystitis model were studied. The results suggest that HF could be beneficial to the renal and hepatic antioxidant system. Thus, HF might be used as a novel therapeutics agent to eliminate interstitial cystitis. |
| Anahtar Kelimeler |
| enzyme activity | expression | hydroxyfasudil | Interstitial cystitis | kidney | liver |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Artificial Cells, Nanomedicine, and Biotechnology |
| Dergi ISSN | 2169-1401 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 10-2018 |
| Cilt No | 46 |
| Sayfalar | 9 / 14 |
| Doi Numarası | 10.1080/21691401.2018.1449120 |
| Makale Linki | https://www.tandfonline.com/doi/full/10.1080/21691401.2018.1449120 |
| Atıf Sayıları | |
| WoS | 6 |
| SCOPUS | 8 |
| Google Scholar | 7 |
