Natural product inhibitors of carbonic anhydrase I and II isoenzymes: osajin and pomiferin
Yazarlar (5)
Prof. Dr. Esra Dilek Erzincan Binali Yıldırım Üniversitesi, Türkiye
Doç. Dr. Hüseyin Serkan Erol Atatürk Üniversitesi, Türkiye
Ahmet Çakır Kilis 7 Aralık Üniversitesi, Türkiye
Prof. Dr. Murat Koç Ankara Yıldırım Beyazıt Üniversitesi, Türkiye
Prof. Dr. Mesut Bünyami Halıcı Atatürk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY (Q3) | ||
| Dergi ISSN | 1381-3455 Dergi Bilgileri (2017) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2017 |
| Kabul Tarihi | 04-03-2017 | Yayınlanma Tarihi | 24-03-2017 |
| Cilt / Sayı / Sayfa | 123 / 4 / 219–224 | DOI | 10.1080/13813455.2017.1303742 |
| Makale Linki | https://www.tandfonline.com/doi/full/10.1080/13813455.2017.1303742 | ||
| UAK Araştırma Alanları |
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| Özet |
| The aim of this study is to purify carbonic anhydrase I and II isoenzymes from human erythrocyte, isolate two natural products osajin (OSJ) and pomiferin (PMF) from Maclura pomifera fruits, and evaluate the in vitro effect of these natural metabolites on these isoenzymes. These natural products may be used as starting points for drug discovery (like drugs used in several therapeutic applications, including antiglaucoma activity). For the purification procedure, the Sepharose-4B-l-tyrosine-sulphonamide affinity chromatography was used. Column chromatography and thin layer chromatography methods were used for isolation of OSJ and PMF from M. pomifera fruits and their chemical structures were elucidated by IR, 1D, and 2D NMR methods. We compared inhibitory effects of these natural products with inhibitory effects of phenolic compounds and found that these products demonstrated average inhibition effects. We thought that this study will give inspiration to scientists interested in this issue. |
| Anahtar Kelimeler |
| Carbonic anhydrase I | carbonic anhydrase II | inhibition | osajin | pomiferin |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |