Pathological effects of prenatal exposure to a 900 MHz electromagnetic field on the 21 day old male rat kidney
Yazarlar (10)
Tolga Mercantepe Recep Tayyip Erdoğan Üniversitesi, Türkiye
Zehra Topal Suzan Recep Tayyip Erdoğan Üniversitesi, Türkiye
Hatice Hancı Ordu Üniversitesi, Türkiye
Sibel Türedi Harran Üniversitesi, Türkiye
Doç. Dr. Hüseyin Serkan Erol Atatürk Üniversitesi, Türkiye
Sevdegül Aydın Mungan Karadeniz Teknik Üniversitesi, Türkiye
Haydar Kaya Karadeniz Teknik Üniversitesi, Türkiye
Prof. Dr. Serdar Çolakoğlu Düzce Üniversitesi, Türkiye
Makale Türü Açık Erişim Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı BIOTECHNIC & HISTOCHEMISTRY
Dergi ISSN 1052-0295 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili İngilizce Basım Tarihi 02-2015
Kabul Tarihi Yayınlanma Tarihi 27-08-2014
Cilt / Sayı / Sayfa 90 / 2 / 93–101 DOI 10.3109/10520295.2014.947322
Makale Linki https://hdl.handle.net/20.500.12684/4040
Özet
We investigated the effects on kidney tissue of 900 megahertz (MHz) EMF applied during the prenatal period. Pregnant rats were exposed to 900 MHz EMF, 1 h/day, on days 13-21 of pregnancy; no procedure was performed on control group pregnant rats or on mothers or newborns after birth. On postnatal day 21, kidney tissues of male rat pups from both groups were examined by light and electron microscopy. Malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) and glutathione levels also were investigated. Light microscopy revealed some degenerative changes in the tubule epithelium, small cystic formations in the primitive tubules and large cysts in the cortico-medullary or medullary regions in the experimental group. Electron microscopy revealed a loss of peritubular capillaries and atypical parietal layer epithelial cells in the experimental group. Biochemical analysis showed significantly increased MDA levels in the experimental group and decreased SOD and CAT levels. EMF applied during the prenatal period can caused pathological changes in kidney tissue in 21-day-old male rats owing to oxidative stress and decreased antioxidant enzyme levels.
Anahtar Kelimeler
Antioxidant enzymes | Cell phone | Electromagnetic field | Kidney | Male rat