Impact of high-dose oleuropein on cisplatin-induced oxidative stress, genotoxicity and pathological changes in rat stomach and lung
Yazarlar (11)
Prof. Dr. Fatime Geyikoğlu Atatürk Üniversitesi, Türkiye
Hatice Işıkgöz
Hakan Önalan
Prof. Dr. Suat Çolak Erzincan Binali Yıldırım Üniversitesi, Türkiye
Doç. Dr. Salim Çeriğ Ağrı İbrahim Çeçen Üniversitesi, Türkiye
Murat Bakır
Mirkhalil Hosseinigouzdagani
Doç. Dr. Kübra Koç Atatürk Üniversitesi, Türkiye
Doç. Dr. Hüseyin Serkan Erol Atatürk Üniversitesi, Türkiye
Prof. Dr. Yavuz Selim Sağlam Atatürk Üniversitesi, Türkiye
Prof. Dr. Serkan Yıldırım Atatürk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | ||
| Dergi ISSN | 1028-6020 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2017 |
| Kabul Tarihi | 04-04-2017 | Yayınlanma Tarihi | 21-04-2017 |
| Cilt / Sayı / Sayfa | 19 / 12 / 1214–1231 | DOI | 10.1080/10286020.2017.1317751 |
| Makale Linki | http://dx.doi.org/10.1080/10286020.2017.1317751 | ||
| UAK Araştırma Alanları |
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| Özet |
| The current systemic treatments of the various solid tumors involve Cisplatin (CIS)-based chemotherapy. Due to its cytotoxicity, this approach is limited. Moreover, the safety of CIS is only discussed especially in breast and stomach cancers. Therefore, we, for the first time, explored the restorative efficacy of oleuropein (OLE), in stomach and lung injuries induced by CIS. Sprague-Dawley rats were divided into eight groups: control CIS, OLE and CIS + OLE. Single dose of (7 mg/kg) CIS was administered intraperitoneally to CIS and CIS + OLE groups. After 24 h, 50, 100 and 200 mg/kg OLE was given for three consecutive days to OLE and CIS + OLE groups. The 8-OH-dG, total oxidative/antioxidant status (TOS/TAS) and malondialdehyde (MDA) levels were evaluated and histopathological analyses were performed on the studied tissues. The results indicated that CIS significantly increased 8-OH-dG, MDA and TOS levels and caused severe tissue damages. However, high dose of OLE induced a significant decrease in the 8-OH-dG, MDA levels, an increase in TAS levels and it restores CIS-induced tissue damages. We hope that the results of this study will provide an impetus for future studies on novel therapeutic strategies including the protective use of oleuropein in gastric and lung cancers due to chemotherapy. |
| Anahtar Kelimeler |
| Chemotherapy drug | histology | lung | oleuropein | oxidative DNA damage | stomach |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |