| Yazarlar |
Buğra Kerget
|
|
Ömer Araz
Atatürk Üniversitesi, Türkiye |
|
Ferhan Kerget
|
Doç. Dr. Hüseyin Serkan EROL
Kastamonu Üniversitesi, Türkiye |
|
Sevilay Özmen
Atatürk Üniversitesi, Türkiye |
|
Zekai Halıcı
Atatürk Üniversitesi, Türkiye |
|
Metin Akgün
Atatürk Üniversitesi, Türkiye |
| Özet |
| In addition to tube drains, pleural empyema is treated with antibiotics and anti-inflammatory drugs. We aimed to evaluate the anti-inflammatory activity of roflumilast combined with linezolid in a rat model of pleural empyema induced by Staphylococcus aureus. A total of 40 rats were divided into 7 groups: sham (n = 4), S. aureus inoculation (n = 6), S. aureus + 10 mg/kg linezolid (n = 6), S. aureus + 5 mg/kg roflumilast (n = 6), S. aureus + 10 mg/kg linezolid + 5 mg/kg roflumilast (n = 6), S. aureus + 10 mg/kg roflumilast (n = 6), and S. aureus + 10 mg/kg linezolid + 10 mg/kg roflumilast (n = 6). Animals were administered linezolid 1 h before and 12 h after inoculation with S. aureus. Roflumilast was administered orally as a single dose 30 min before inoculation with S. aureus. Compared to linezolid treatment alone, linezolid combined with 5 mg/kg roflumilast significantly improved TNF-α, IL-1β, vasodilation/congestion, and tissue/pleural polynuclear leukocyte (PNL) infiltration (p < 0.05). Linezolid combined with 10 mg/kg roflumilast also provided a significant improvement in TNF-α, IL-1β, IL-6, endothelin-1, vasodilation/congestion, mesothelial cell damage, lung tissue PNL, and pleural PNL compared to linezolid alone (p < 0.05). Due to its anti-inflammatory effects and significant impact on recovery, roflumilast can be used in conjunction with antibiotherapy for the treatment of pleural empyema. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | JAPANESE JOURNAL OF INFECTIOUS DISEASES |
| Dergi ISSN | 1344-6304 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2020 |
| Cilt No | 73 |
| Sayı | 1 |
| Sayfalar | 1 / 7 |
| Doi Numarası | 10.7883/yoken.JJID.2019.164 |
| Makale Linki | https://www.jstage.jst.go.jp/article/yoken/73/1/73_JJID.2019.164/_pdf/-char/en |
| Atıf Sayıları | |
| WoS | 1 |
| Google Scholar | 1 |
