| Yazarlar |
Aliseydi Bozkurt
Erzincan Binali Yıldırım Üniversitesi, Türkiye |
|
Mehmet Karabakan
|
|
Merve Aydın Terzioğlu
Kto Karatay Üniversitesi, Türkiye |
|
Sinem Gümüştaş
|
|
Didem Onk
Erzincan Binali Yıldırım Üniversitesi, Türkiye |
|
Cebrail Gürsul
Erzincan Binali Yıldırım Üniversitesi, Türkiye |
Doç. Dr. Hüseyin Serkan EROL
Kastamonu Üniversitesi, Türkiye |
| Özet |
| Aim: Diabetes mellitus (DM) is known to have side effects on sexual and reproductive functions in males. The aim of current study was to investigate the effect of melatonin treatment on spermatogenesis and serum inflammatory cytokine levels in diabetic rats.Material and Method: Eighteen adult Wistar albino male rats were divided randomly into three groups each containing 6 rats; control group (group 1), diabetic group (group 2), diabetic treated with melatonin group (group 3). Experimental diabetes was obtained by administrating 50 mg/kg streptozotocin. Melatonin treatment was administered intraperitoneally for 7 days at a dose of 20 mg, daily. Serum levels of interleukin-1 beta (IL-1β), interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF-α) were assayed. Spermatogenesis was evaluated according to Johnsen score at immunopathological examination.Results: The Johnsen scores in control, diabetic and treatment groups were 9.78, 8.91, and 9.61, respectively. Spermatogenesis was negatively affected in diabetic rats and significantly improved with melatonin therapy (p<0.05). The serum levels of TNF-α in diabetic rats were observed to be increased compared to the control group (p<0.05). The levels of serum IL-1β and TNF- α were significantly decreased with melatonin treatment. IL-6 levels were not different among the three groups (p=0.248).Conclusions: In the present study, intraperitoneal melatonin treatment was determined to have a positive effect of on spermatogenesis and caused a decrease in serum inflammatory cytokine levels in diabetic rats. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | Ulusal alan endekslerinde (TR Dizin, ULAKBİM) yayımlanan tam makale |
| Dergi Adı | Annals of Medical Research |
| Dergi ISSN | 2636-7688 |
| Dergi Tarandığı Indeksler | TR DİZİN |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2019 |
| Cilt No | 26 |
| Sayı | 1 |
| Sayfalar | 12 / 16 |
| Doi Numarası | 10.5455/annalsmedres.2018.09.192 |
| Makale Linki | https://www.ejmanager.com/fulltextpdf.php?mno=9376 |
| Atıf Sayıları | |
| Google Scholar | 7 |
