| Yazarlar |
İlyas Bozkurt
Ardahan Üniversitesi, Türkiye |
|
Esra Dilek
Erzincan Binali Yıldırım Üniversitesi, Türkiye |
Doç. Dr. Hüseyin Serkan EROL
Atatürk Üniversitesi, Türkiye |
|
Ahmet Çakır
Kilis 7 Aralık Üniversitesi, Türkiye |
|
Ergin Hamzaoğlu
Gazi Üniversitesi, Türkiye |
|
Murat Koç
Ankara Yıldırım Beyazıt Üniversitesi, Türkiye |
|
Osman Nuri Keleş
Atatürk Üniversitesi, Türkiye |
|
Mesut Bünyami Halıcı
Atatürk Üniversitesi, Türkiye |
| Özet |
| Previously, water extract of Maclura pomifera plant has been found effective on gastric damage. In this study, pomiferin product was purified from this plant by thin-layer chromatography method and its structure was elucidated by nuclear magnetic resonance methods. Its antiulcer effect was investigated on indomethacin-induced gastric damage in rats. For this study, a total of 36 Sprague Dawley female rats were divided into six groups such as healthy, control, reference, and three treatment groups (n = 6 each). Ranitidine (Ulcuran® 25 mg/ml vial) was used as reference. Biochemically, lipid peroxidation, and glutathione levels as well as superoxide dismutase, catalase, myeloperoxidase, and cyclooxygenase isoenzymes activities were measured in stomach tissues. Comparing with healthy group, ulcerative area was observed in control group (only administered to indomethacin group). However, Ulcerative area in stomach tissues of rats administered of all doses of pomiferin and ranitidine showed significant decrease (p < 0.05). Also, there were significant changes at the antioxidant levels (lipid peroxidation, glutathione, superoxide dismutase, and catalase) and some important enzyme activities (myeloperoxidase, cyclooxygenase isoenzymes). We found that pomiferin was effective on gastric damage induced by indomethacin. This effect was thought to be caused by positive changes in the antioxidant system. |
| Anahtar Kelimeler |
| Antioxidant system | Maclura pomifera | Pomiferin | Ulcer | İndomethacin |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | MEDICINAL CHEMISTRY RESEARCH |
| Dergi ISSN | 1054-2523 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 09-2017 |
| Cilt No | 26 |
| Sayı | 9 |
| Sayfalar | 2048 / 2056 |
| Doi Numarası | 10.1007/s00044-017-1913-y |
| Makale Linki | http://link.springer.com/10.1007/s00044-017-1913-y |
| Atıf Sayıları | |
| WoS | 9 |
| SCOPUS | 11 |
| Google Scholar | 15 |
