| Yazarlar |
Ahmet Topal
Atatürk Üniversitesi, Türkiye |
|
Muhammed Atamanalp
Atatürk Üniversitesi, Türkiye |
|
Ertan Oruç
Selçuk Üniversitesi, Türkiye |
|
Mesut Bünyami Halıcı
Atatürk Üniversitesi, Türkiye |
|
Melda Şişecioğlu
Atatürk Üniversitesi, Türkiye |
Doç. Dr. Hüseyin Serkan EROL
Atatürk Üniversitesi, Türkiye |
|
Arzu Gergit
|
|
Bahar Yılmaz
Karamanoğlu Mehmetbey Üniversitesi, Türkiye |
| Özet |
| The aim of this study was to determine the biochemical, immunohistochemical, and histopathological effects of nickel chloride (Ni) in the rainbow trout brain. Fish were exposed to Ni concentrations (1 mg/L and 2 mg/L) for 21 days. At the end of the experimental period, brain tissues were taken from all fish for c-Fos activity and histopathological examination and determination of acetylcholinesterase (AChE), superoxide dismutase (SOD), catalase (CAT) enzyme activities, lipid peroxidation (LPO), and glutathione (GSH) levels. Our results showed that Ni treatment caused a significant increase in the brain SOD activity and in LPO and GSH levels (p < 0.05), but it significantly decreased AChE and CAT enzyme activities (p < 0.05). Strong induction in c-Fos was observed in some cerebral and cerebellar regions of fish exposed to Ni concentrations when compared with the control group. However, c-Fos activity was decreased in necrotic Purkinje cells. Brain tissues were characterized by demyelination and necrotic changes. These results suggested that Ni treatment causes oxidative stress, changes in c-Fos activity, and histopathological damage in the fish brain. |
| Anahtar Kelimeler |
| Brain | c-Fos | Fish | Nickel | Oxidative stress | Toxicity |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | FISH PHYSIOLOGY AND BIOCHEMISTRY |
| Dergi ISSN | 0920-1742 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 06-2015 |
| Cilt No | 41 |
| Sayı | 3 |
| Sayfalar | 625 / 634 |
| Doi Numarası | 10.1007/s10695-015-0033-1 |
| Makale Linki | http://link.springer.com/10.1007/s10695-015-0033-1 |
| Atıf Sayıları | |
| WoS | 45 |
| SCOPUS | 46 |
| Google Scholar | 59 |
