| Yazarlar |
Prof. Dr. Zafer ERGÜL
Kastamonu Üniversitesi, Türkiye |
Zülal Kaptan
|
|
Ayhan Kars
Türkiye |
|
Gülşah Biçer
Türkiye |
|
Çetin Kılınç
Türkiye |
|
Emine Petekkaya
Türkiye |
|
Nilay Çöplü
Türkiye |
| Özet |
| Introduction: COVID-19 infection develops neurologic symptoms such as smell and taste loss. We aimed to determine the volumetric changes in the brain and correlation of possible related biochemical parameters and endocannabinoid levels after COVID-19 recovery. Methods: Brain magnetic resonance images of recovered COVID-19 patients and healthy volunteers, whose olfactory and gustatory scores were obtained through a questionnaire, were taken, and the volumes of the brain regions associated with taste and smell were measured by automatic and semiautomatic methods. Endocannabinoids (EC), which are critical in the olfactory system, and vitamin B12, zinc, iron, ferritin, thyroid-stimulating hormone (TSH), and thyroxine (T4) levels, which are reported to have possible roles in olfactory disorders, were measured in peripheral blood. Results: Taste and smell disorder scores and EC levels were found to be higher in recovered COVID-19 patients compared to controls. EC levels were negatively correlated with bilateral entorhinal cortex (ENT) volumes in the COVID-19 group. Subgenual anterior cingulate cortex volumes showed correlations with gustatory complaints and ferritin in recovered COVID-19 patients. Conclusions: The critical finding of our study is the high EC levels and negative correlation between EC levels and left ENT volumes in recovered COVID-19 patients. Implications: It is possible that ECs are potential neuromodulators in many conditions leading to olfactory disorders, including COVID-19. |
| Anahtar Kelimeler |
| Ageusia | Anosmia | COVID-19 | Endocannabinoids | Voxel-based morphometry |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Chemosensory Perception |
| Dergi ISSN | 1936-5802 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q3 |
| Makale Dili | İngilizce |
| Basım Tarihi | 10-2022 |
| Cilt No | 15 |
| Sayı | 12 |
| Sayfalar | 1 / 10 |
| Doi Numarası | 10.1007/s12078-022-09301-1 |
| Makale Linki | www.springer.com/journal/12078 |
| Atıf Sayıları |
