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Can the preemptive use of lornoxicam or paracetamol prevent pain after inguinal hernia repair? A randomized prospective double-blind placebo controlled trial   
Yazarlar
Hüseyin Alp Alptekin
Türkiye
Prof. Dr. Zafer ERGÜL Prof. Dr. Zafer ERGÜL
Kastamonu Üniversitesi, Türkiye
Ercan Sönmez
Türkiye
Celil Uğurlu
Türkiye
İsmail Hakan Kulaçoğlu
Türkiye
Özet
INTRODUCTION: Nonsteroidal anti-inflammatory drugs have become a popular part of multimodal analgesic regimens particularly in ambulatory surgery. This study was designed to search the efficacy of preoperative administration of lornoxicam or paracetamol in patients who underwent open inguinal hernia repair. MATERIALS AND METHODS: American Society of Anesthesiologists Classification (ASA) I-III male patients with unilateral primary inguinal hernia scheduled for elective prosthetic repair under general anesthesia were randomly assigned to three groups. Group I patients were infused 100-ml normal saline 30 min before anesthesia (placebo), whereas Group II and Group III patients were given 8 mg lornoxicam or 1,000 mg paracetamol intravenously in 100-ml normal saline. Postoperative pain was treated with patient controlled intravenous morphine. Postoperative pain scores were evaluated with visual analog scale (VAS) in the recovery room and at 1 st, 6 th, 12 th, and 24 th hours postoperatively in all groups. Total amount of analgesics. Liker scale and SF-36 form was also used at 4th week follow-up in order assess quality of life. RESULTS: Totally 88 patients were completed the study (G1 = 28, G2 = 30, and G3 = 30). Preemptive use of both lornoxicam and paracetamol resulted in significantly lower recovery room VAS scores in comparison with placebo group (3.93, 3.73, and 5.25). Both lornoxicam and paracetamol groups (G2 and G3) displayed better results at 12 th h than placebo group (P = 0.04). VAS scores at 24 th hour were similar in three groups. Total morphine consumptions were also similar between the groups at all times. Total postoperative 1-week oral analgesic use was significantly less in G2 (lornoxicam), and G3 (paracetamol) in comparison with G1 (placebo). Quality of life indicators in Likert Scale and SF-36 form were also not different. CONCLUSION: Preemptive use of both lornoxicam and paracetamol may be effective in early postoperative pain control in patients undergo elective open inguinal hernia repair. However, there seems to be no difference between the efficacies of the two agents.
Anahtar Kelimeler
Inguinal hernia | Lichtenstein | lornoxicam | paracetamol | preemptive analgesia
Makale Türü Özgün Makale
Makale Alt Türü SCOPUS dergilerinde yayımlanan tam makale
Dergi Adı International Journal of Abdominal Wall and Hernia Surgery
Dergi ISSN 1265-4906
Dergi Tarandığı Indeksler scopus
Makale Dili İngilizce
Basım Tarihi 10-2022
Cilt No 5
Sayı 4
Sayfalar 185 / 191
Doi Numarası 10.4103/ijawhs.ijawhs_43_22
Makale Linki Website: www.herniasurgeryjournal.org