Pharmacokinetics of cefquinome in rainbow trout(Oncorhynchus mykiss) after intravascular, intraperitoneal, and oral administrations
Yazarlar (7)
Doç. Dr. Duygu Durna Çorum Hatay Mustafa Kemal Üniversitesi, Türkiye
Prof. Dr. Orhan Çorum Hatay Mustafa Kemal Üniversitesi, Türkiye
Doç. Dr. Ertuğrul TERZİ Kastamonu Üniversitesi, Türkiye
Doç. Dr. Devran Coşkun Siirt Üniversitesi, Türkiye
Doç. Dr. Soner BİLEN Kastamonu Üniversitesi, Türkiye
Doç. Dr. Gül Çetin Erzincan Binali Yıldırım Üniversitesi, Türkiye
Prof. Dr. Kamil Üney Selçuk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Veterinary Pharmacology and Therapeutics (Q2) | ||
| Dergi ISSN | 0140-7783 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 11-2022 |
| Kabul Tarihi | 12-08-2022 | Yayınlanma Tarihi | 24-08-2022 |
| Cilt / Sayı / Sayfa | 45 / 6 / 578–583 | DOI | 10.1111/jvp.13091 |
| Makale Linki | http://dx.doi.org/10.1111/jvp.13091 | ||
| UAK Araştırma Alanları |
Su Kalitesi ve Su Kirliliği
|
||
| Özet |
| This study aimed to determine the pharmacokinetics and bioavailability of cefquinome in rainbow trout (Oncorhynchus mykiss) following intravascular (IV), intraperitoneal (IP), and oral (PO) administrations at 14 ± 1°C. In this study, three hundred and six clinically healthy rainbow trout (110–140 g) were used. The fish received single IV, IP, and PO injections of cefquinome at 10 mg/kg dose. The plasma concentrations of cefquinome were measured using HPLC‐UV and were evaluated using non‐compartmental analysis. Cefquinome was measured up to 96 h for PO route and 144 h for IV and IP routes in plasma. Following IV administration, t1/2ʎz, ClT, and Vdss were 18.85 h, 0.037 L/h/kg, and 0.84 L/kg, respectively. The Cmax of IP and PO routes was 9.75 and 1.64 μg/ml, respectively. The bioavailability following IP and PO administrations was 59.46% and 12.33%, respectively. Cefquinome at 10 mg/kg … |
| Anahtar Kelimeler |
| bioavailability | cefquinome | pharmacokinetics | rainbow trout |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 12 |
| Scopus | 12 |
| Google Scholar | 15 |