| Yazarlar |
Duygu Durna Çorum
Hatay Mustafa Kemal Üniversitesi, Türkiye |
|
Orhan Çorum
Hatay Mustafa Kemal Üniversitesi, Türkiye |
Doç. Dr. Ertuğrul TERZİ
Kastamonu Üniversitesi, Türkiye |
|
Devran Coşkun
Siirt Üniversitesi, Türkiye |
Doç. Dr. Soner BİLEN
Türkiye |
|
Gül Çetin
Erzincan Binali Yıldırım Üniversitesi, Türkiye |
|
Kamil Üney
Selçuk Üniversitesi, Türkiye |
| Özet |
| This study aimed to determine the pharmacokinetics and bioavailability of cefquinome in rainbow trout (Oncorhynchus mykiss) following intravascular (IV), intraperitoneal (IP), and oral (PO) administrations at 14 ± 1°C. In this study, three hundred and six clinically healthy rainbow trout (110–140 g) were used. The fish received single IV, IP, and PO injections of cefquinome at 10 mg/kg dose. The plasma concentrations of cefquinome were measured using HPLC-UV and were evaluated using non-compartmental analysis. Cefquinome was measured up to 96 h for PO route and 144 h for IV and IP routes in plasma. Following IV administration, t1/2ʎz, ClT, and Vdss were 18.85 h, 0.037 L/h/kg, and 0.84 L/kg, respectively. The Cmax of IP and PO routes was 9.75 and 1.64 μg/ml, respectively. The bioavailability following IP and PO administrations was 59.46% and 12.33%, respectively. Cefquinome at 10 mg/kg dose may maintain T > MIC above 40% at 72 and 96 h intervals, respectively, following the IP and IV routes for bacteria with MIC values of ≤2 μg/ml and at 24 h intervals following the PO route for bacteria with MIC value of ≤0.75 μg/ml. However, further studies are needed to determine in vitro and in vivo antibacterial efficacy and multiple dosage regimens of cefquinome against pathogens isolated from rainbow trout. |
| Anahtar Kelimeler |
| bioavailability | cefquinome | pharmacokinetics | rainbow trout |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS |
| Dergi ISSN | 0140-7783 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 11-2022 |
| Cilt No | 45 |
| Sayı | 6 |
| Sayfalar | 578 / 583 |
| Doi Numarası | 10.1111/jvp.13091 |
| Makale Linki | http://dx.doi.org/10.1111/jvp.13091 |
| Atıf Sayıları | |
| WoS | 8 |
| SCOPUS | 7 |
| Google Scholar | 8 |
