Pharmacokinetics and bioavailability of meloxicam in rainbow trout ( Oncorhynchus mykiss ) broodstock following intravascular, intramuscular, and oral administrations
Yazarlar (4)
Prof. Dr. Orhan Çorum Kastamonu Üniversitesi, Türkiye
Doç. Dr. Ertuğrul TERZİ Kastamonu Üniversitesi, Türkiye
Doç. Dr. Duygu Durna Çorum Kastamonu Üniversitesi, Türkiye
Prof. Dr. Kamil Üney Selçuk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Veterinary Pharmacology and Therapeutics (Q3) | ||
| Dergi ISSN | 0140-7783 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 03-2022 |
| Kabul Tarihi | 31-10-2021 | Yayınlanma Tarihi | 14-11-2021 |
| Cilt / Sayı / Sayfa | 45 / 2 / 213–219 | DOI | 10.1111/jvp.13031 |
| Makale Linki | http://dx.doi.org/10.1111/jvp.13031 | ||
| UAK Araştırma Alanları |
Su Ürünleri Hastalıkları
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| Özet |
| The pharmacokinetics and bioavailability of meloxicam were investigated after single intravascular (IV), intramuscular (IM), and oral dose of 1 mg/kg in rainbow trout broodstock at 11 ± 1.2°C. A total of 36 healthy rainbow trout (Oncorhynchus mykiss) broodstock weighing 1.40 ± 0.26 kg was used for the investigation. Plasma concentrations of meloxicam were measured with high‐performance liquid chromatography‐ultraviolet detection, and pharmacokinetic parameters were calculated by non‐compartmental analysis. The elimination half‐life for IV, IM, and oral routes was 3.63, 4.55, and 2.95 h, respectively. The IV route for meloxicam showed the total clearance of 0.05 L/h/kg and volume of distribution at a steady state of 0.20 L/kg. The peak plasma concentration was 2.97 μg/ml for the IM route and 0.84 μg/ml for the oral route. The bioavailability was 78.45% for the IM route and 21.48% for the oral route. Meloxicam … |
| Anahtar Kelimeler |
| bioavailability | broodstock | meloxicam | pharmacokinetics | rainbow trout |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 14 |
| Scopus | 15 |
| Google Scholar | 17 |