Yazarlar |
Kamil Üney
Selçuk Üniversitesi, Türkiye |
Doç. Dr. Ertuğrul TERZİ
Kastamonu Üniversitesi, Türkiye |
Duygu Durna Çorum
Kastamonu Üniversitesi, Türkiye |
Arş. Gör. Dr. Rahmi Can ÖZDEMİR
Türkiye |
Doç. Dr. Soner BİLEN
Kastamonu Üniversitesi, Türkiye |
Orhan Çorum
Türkiye |
Özet |
The pharmacokinetic of enrofloxacin was investigated in brown trout (Salmo trutta) following oral administration of 10, 20, and 40 mg/kg doses at 11 ± 1.5 °C. Furthermore, MICs of en-rofloxacin against Aeromonas hydrophila and A. sobria were determined. The plasma concentrations of enrofloxacin and ciprofloxacin were determined using HPLC–UV and analyzed by non‐compart-mental method. Following oral administration at dose of 10 mg/kg, total clearance (CL/F), area under the concentration–time curve (AUC0−∞) and peak plasma concentrations (Cmax) were 41.32 mL/h/kg, 242.02 h*μg/mL and 4.63 μg/mL, respectively. When compared to 10 mg/kg dose, the dose‐normalized AUC0–∞ and Cmax were increased by 56.30% and 30.08%, respectively, while CL/F decreased by 38.4% at 40 mg/kg dose, suggesting the non‐linearity. Ciprofloxacin was not detected in the all of plasma samples. The MIC values of enrofloxacin were ranged 0.0625–4 μg/mL for A. hydrophila and 0.0625–2 μg/mL for A. sobria. The oral administration of enrofloxacin at 10 (for 192 h) and 20 (for 240 h) mg/kg doses provided the AUC of enrofloxacin equal to 1.23 and 1.96‐fold MICs, respectively, for A. hydrophila and A. sobria with the MIC90 values of 1 μg/mL. However, further researches are needed on the PK/PD study of enrofloxacin for the successful treatment of infections caused by A. hydrophila and A. sobria in brown trout. |
Anahtar Kelimeler |
Brown trout | Enrofloxacin | Pharmacodynamics | Pharmacokinetics |
Makale Türü | Özgün Makale |
Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
Dergi Adı | ANIMALS |
Dergi ISSN | 2076-2615 |
Dergi Tarandığı Indeksler | SCI-Expanded |
Dergi Grubu | Q1 |
Makale Dili | Türkçe |
Basım Tarihi | 11-2021 |
Cilt No | 11 |
Sayı | 11 |
Sayfalar | 3086 / 3086 |
Doi Numarası | 10.3390/ani11113086 |
Makale Linki | http://dx.doi.org/10.3390/ani11113086 |