Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Integration of Enrofloxacin Following Single Oral Administration of Different Doses in Brown Trout (Salmo trutta)

Üney, Kamil; TERZİ, Ertuğrul; Çorum, Duygu Durna; ÖZDEMİR, Rahmi Can; BİLEN, Soner; Çorum, Orhan

doi:10.3390/ani11113086

Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Integration of Enrofloxacin Following Single Oral Administration of Different Doses in Brown Trout (Salmo trutta)

Yazarlar
Kamil Üney Selçuk Üniversitesi, Türkiye
Doç. Dr. Ertuğrul TERZİ Kurum Bilgileri Devrekani Türkiye Odalar ve Borsalar Birliği Meslek Yüksekokulu Veterinerlik Laborant ve Veteriner Sağlık Programı Özgeçmiş Sayfası İletişim Bilgileri: (366)280-1000 Kastamonu Üniversitesi, Türkiye
Duygu Durna Çorum Kastamonu Üniversitesi, Türkiye
Arş. Gör. Dr. Rahmi Can ÖZDEMİR Kurum Bilgileri Mühendislik ve Mimarlık Fakültesi Gıda Mühendisliği Gıda Bilimleri Özgeçmiş Sayfası İletişim Bilgileri: (366)280-2309 Türkiye
Doç. Dr. Soner BİLEN Kurum Bilgileri İhsangazi Meslek Yüksekokulu Veterinerlik Laborant ve Veteriner Sağlık Programı Özgeçmiş Sayfası İletişim Bilgileri: (366)280-2308 Kastamonu Üniversitesi, Türkiye
Orhan Çorum Türkiye

Özet

The pharmacokinetic of enrofloxacin was investigated in brown trout (Salmo trutta) following oral administration of 10, 20, and 40 mg/kg doses at 11 ± 1.5 °C. Furthermore, MICs of en-rofloxacin against Aeromonas hydrophila and A. sobria were determined. The plasma concentrations of enrofloxacin and ciprofloxacin were determined using HPLC–UV and analyzed by non‐compart-mental method. Following oral administration at dose of 10 mg/kg, total clearance (CL/F), area under the concentration–time curve (AUC0−∞) and peak plasma concentrations (Cmax) were 41.32 mL/h/kg, 242.02 h*μg/mL and 4.63 μg/mL, respectively. When compared to 10 mg/kg dose, the dose‐normalized AUC0–∞ and Cmax were increased by 56.30% and 30.08%, respectively, while CL/F decreased by 38.4% at 40 mg/kg dose, suggesting the non‐linearity. Ciprofloxacin was not detected in the all of plasma samples. The MIC values of enrofloxacin were ranged 0.0625–4 μg/mL for A. hydrophila and 0.0625–2 μg/mL for A. sobria. The oral administration of enrofloxacin at 10 (for 192 h) and 20 (for 240 h) mg/kg doses provided the AUC of enrofloxacin equal to 1.23 and 1.96‐fold MICs, respectively, for A. hydrophila and A. sobria with the MIC90 values of 1 μg/mL. However, further researches are needed on the PK/PD study of enrofloxacin for the successful treatment of infections caused by A. hydrophila and A. sobria in brown trout.

Anahtar Kelimeler

Brown trout | Enrofloxacin | Pharmacodynamics | Pharmacokinetics

Makale Türü	Özgün Makale
Makale Alt Türü	SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı	ANIMALS
Dergi ISSN	2076-2615
Dergi Tarandığı Indeksler	SCI-Expanded
Dergi Grubu	Q1
Makale Dili	Türkçe
Basım Tarihi	11-2021
Cilt No	11
Sayı	11
Sayfalar	3086 / 3086
Doi Numarası	10.3390/ani11113086
Makale Linki	http://dx.doi.org/10.3390/ani11113086

BM Sürdürülebilir Kalkınma Amaçları

Atıf Sayıları
WoS	16
SCOPUS	17
Google Scholar	22

Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Integration of Enrofloxacin Following Single Oral Administration of Different Doses in Brown Trout (Salmo trutta)

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Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Integration of Enrofloxacin Following Single Oral Administration of Different Doses in Brown Trout (Salmo trutta)

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