Pharmacokinetics and Bioavailability of Carprofen in Rainbow Trout (Oncorhynchus mykiss) Broodstock
Yazarlar (4)
Prof. Dr. Kamil Üney Selçuk Üniversitesi, Türkiye
Doç. Dr. Duygu Durna Çorum Kastamonu Üniversitesi, Türkiye
Doç. Dr. Ertuğrul TERZİ Kastamonu Üniversitesi, Türkiye
Prof. Dr. Orhan Çorum Kastamonu Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
|
||
| Dergi Adı | Pharmaceutics (Q1) | ||
| Dergi ISSN | 1999-4923 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 07-2021 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 30-06-2021 |
| Cilt / Sayı / Sayfa | 13 / 7 / 990–0 | DOI | 10.3390/pharmaceutics13070990 |
| Makale Linki | http://dx.doi.org/10.3390/pharmaceutics13070990 | ||
| UAK Araştırma Alanları |
Su Kalitesi ve Su Kirliliği
|
||
| Özet |
| The aim of this study was to determine the pharmacokinetics of carprofen following intravenous (IV), intramuscular (IM) and oral routes to rainbow trout (Oncorhynchus mykiss) broodstock at temperatures of 10 ± 1.5 °C. In this study, thirty-six healthy rainbow trout broodstock (body weight, 1.45 ± 0.30 kg) were used. The plasma concentrations of carprofen were determined using high-performance liquid chromatography and pharmacokinetic parameters were calculated using non-compartmental analysis. Carprofen was measured up to 192 h for IV route and 240 h for IM, and oral routes in plasma. The elimination half-life (t1/2λz) was 30.66, 46.11, and 41.08 h for IV, IM and oral routes, respectively. Carprofen for the IV route showed the total clearance of 0.02 L/h/kg and volume of distribution at steady state of 0.60 L/kg. For IM and oral routes, the peak plasma concentration (Cmax) was 3.96 and 2.52 μg/mL with the time to reach Cmax of 2 and 4 h, respectively. The bioavailability was 121.89% for IM route and 78.66% for oral route. The favorable pharmacokinetic properties such as the good bioavailability and long t1/2λz for IM and oral route of carprofen suggest the possibility of its effective use for the treatment of various conditions in broodstock. |
| Anahtar Kelimeler |
| Bioavailability | Broodstock | Carprofen | Pharmacokinetics | Rainbow trout |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 21 |
| Scopus | 23 |
| Google Scholar | 24 |