| Yazarlar |
Kamil Üney
Selçuk Üniversitesi, Türkiye |
|
Duygu Durna Çorum
Türkiye |
Doç. Dr. Ertuğrul TERZİ
Kastamonu Üniversitesi, Türkiye |
|
Orhan Çorum
Türkiye |
| Özet |
| The aim of this study was to determine the pharmacokinetics of carprofen following intravenous (IV), intramuscular (IM) and oral routes to rainbow trout (Oncorhynchus mykiss) broodstock at temperatures of 10 ± 1.5◦C. In this study, thirty-six healthy rainbow trout broodstock (body weight, 1.45 ± 0.30 kg) were used. The plasma concentrations of carprofen were determined using high-performance liquid chromatography and pharmacokinetic parameters were calculated using non-compartmental analysis. Carprofen was measured up to 192 h for IV route and 240 h for IM, and oral routes in plasma. The elimination half-life (t1/2λz) was 30.66, 46.11, and 41.08 h for IV, IM and oral routes, respectively. Carprofen for the IV route showed the total clearance of 0.02 L/h/kg and volume of distribution at steady state of 0.60 L/kg. For IM and oral routes, the peak plasma concentration (Cmax) was 3.96 and 2.52 µg/mL with the time to reach Cmax of 2 and 4 h, respectively. The bioavailability was 121.89% for IM route and 78.66% for oral route. The favorable pharmacokinetic properties such as the good bioavailability and long t1/2λz for IM and oral route of carprofen suggest the possibility of its effective use for the treatment of various conditions in broodstock. |
| Anahtar Kelimeler |
| Bioavailability | Broodstock | Carprofen | Pharmacokinetics | Rainbow trout |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | PHARMACEUTICS |
| Dergi ISSN | 1999-4923 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q1 |
| Makale Dili | Türkçe |
| Basım Tarihi | 07-2021 |
| Cilt No | 13 |
| Sayı | 7 |
| Doi Numarası | 10.3390/pharmaceutics13070990 |
| Makale Linki | http://dx.doi.org/10.3390/pharmaceutics13070990 |
| Atıf Sayıları | |
| WoS | 12 |
| SCOPUS | 13 |
| Google Scholar | 15 |
